MOT14_MOUSE
ID MOT14_MOUSE Reviewed; 512 AA.
AC Q8K1C7; Q9D1K0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Monocarboxylate transporter 14;
DE Short=MCT 14;
DE AltName: Full=Solute carrier family 16 member 14;
GN Name=Slc16a14; Synonyms=Mct14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22782.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC33953.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003423; BAB22782.1; ALT_INIT; mRNA.
DR EMBL; AK049846; BAC33953.1; ALT_INIT; mRNA.
DR EMBL; BC023456; AAH23456.1; -; mRNA.
DR CCDS; CCDS15106.1; -.
DR RefSeq; NP_082197.1; NM_027921.1.
DR RefSeq; XP_006496614.1; XM_006496551.3.
DR AlphaFoldDB; Q8K1C7; -.
DR SMR; Q8K1C7; -.
DR STRING; 10090.ENSMUSP00000027422; -.
DR iPTMnet; Q8K1C7; -.
DR PhosphoSitePlus; Q8K1C7; -.
DR PaxDb; Q8K1C7; -.
DR PRIDE; Q8K1C7; -.
DR ProteomicsDB; 290280; -.
DR Antibodypedia; 50076; 80 antibodies from 19 providers.
DR DNASU; 71781; -.
DR Ensembl; ENSMUST00000027422; ENSMUSP00000027422; ENSMUSG00000026220.
DR GeneID; 71781; -.
DR KEGG; mmu:71781; -.
DR UCSC; uc007btd.1; mouse.
DR CTD; 151473; -.
DR MGI; MGI:1919031; Slc16a14.
DR VEuPathDB; HostDB:ENSMUSG00000026220; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000160895; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q8K1C7; -.
DR OMA; CSEYGWR; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q8K1C7; -.
DR TreeFam; TF313792; -.
DR BioGRID-ORCS; 71781; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Slc16a14; mouse.
DR PRO; PR:Q8K1C7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8K1C7; protein.
DR Bgee; ENSMUSG00000026220; Expressed in right kidney and 68 other tissues.
DR ExpressionAtlas; Q8K1C7; baseline and differential.
DR Genevisible; Q8K1C7; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..512
FT /note="Monocarboxylate transporter 14"
FT /id="PRO_0000288924"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..512
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 512 AA; 56476 MW; 347B725EE7103A63 CRC64;
MYTSHEDIGY DLEDDRKAKN KKTLKPHPDI DGGWAWMMVL SSFFVHILIM GSQMALGVLN
VEWLEEFHQS RGLTAWVSSL SMGITLIVGP FIGLFINTCG CRQTAIIGGL VNSLGWVLSA
YAANVQSLFI TFGVAAGLGS GMAYLPAVVM VGRYFQKRRA LAQGLSTTGT GFGTFLMTVL
LKYLCAEYGW RNAMFIQGAL SLNLCVCGAL MRPLSPEKLE NCPEAEEPCA LPAYSTESVK
SGGPLGMAEE QDRRPGNEEM VCDLQTQECQ GQTHPRKNVC AFRVLKTVSQ LTVQVRRGFR
DWHSGYFGTA SLFTNRMFVA FIFWALFAYS SFVIPFIHLP EIVSLYNLSE QNDTFPLTSI
IAILHIFGKV ILGAVADLPC ISVWNVFLIA NFTLVLSIFL LPLMHTYASL AVICALIGFS
SGYFSLMPVV TEDLVGTEHL ANAYGIIICA NGISALLGPP FAGWIFDITQ KYDFSFYICG
LLYMVGILFL LIQPCIQMID QSRRKCIEGA HV
