ID   MOT1_MERUN              Reviewed;          76 AA.
AC   O35439;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Monocarboxylate transporter 1;
DE            Short=MCT 1;
DE   AltName: Full=Solute carrier family 16 member 1;
DE   Flags: Fragment;
GN   Name=SLC16A1; Synonyms=MCT1;
OS   Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Gerbillinae; Meriones.
OX   NCBI_TaxID=10047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stria vascularis;
RX   PubMed=9447934; DOI=10.1016/s0378-5955(97)00165-2;
RA   Shimozono M., Scofield M.A., Wangemann P.;
RT   "Functional evidence for a monocarboxylate transporter (MCT) in strial
RT   marginal cells and molecular evidence for MCT1 and MCT2 in stria
RT   vascularis.";
RL   Hear. Res. 114:213-222(1997).
CC   -!- FUNCTION: Proton-coupled monocarboxylate transporter. Catalyzes the
CC       rapid transport across the plasma membrane of many monocarboxylates
CC       such as lactate, pyruvate, branched-chain oxo acids derived from
CC       leucine, valine and isoleucine, and the ketone bodies acetoacetate,
CC       beta-hydroxybutyrate and acetate. Depending on the tissue and on
CC       cicumstances, mediates the import or export of lactic acid and ketone
CC       bodies. Required for normal nutrient assimilation, increase of white
CC       adipose tissue and body weight gain when on a high-fat diet. Plays a
CC       role in cellular responses to a high-fat diet by modulating the
CC       cellular levels of lactate and pyruvate, small molecules that
CC       contribute to the regulation of central metabolic pathways and insulin
CC       secretion, with concomitant effects on plasma insulin levels and blood
CC       glucose homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BSG; interaction mediates SLC16A1 targeting to
CC       the plasma membrane (By similarity). Interacts with EMB; interaction
CC       mediates SLC16A1 targeting to the plasma membrane (By similarity).
CC       {ECO:0000250|UniProtKB:P53985, ECO:0000250|UniProtKB:P53987}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P53985};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; AF029766; AAB84218.1; -; mRNA.
DR   AlphaFoldDB; O35439; -.
DR   SMR; O35439; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035879; P:plasma membrane lactate transport; ISS:UniProtKB.
DR   InterPro; IPR030757; MCT1.
DR   PANTHER; PTHR11360:SF24; PTHR11360:SF24; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           <1..>76
FT                   /note="Monocarboxylate transporter 1"
FT                   /id="PRO_0000211382"
FT   TRANSMEM        <1..18
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         76
SQ   SEQUENCE   76 AA;  8269 MW;  736FA628B792DC25 CRC64;
     LSILAFVDMV ARPSMGLAAN TKWIRPRIQY FFAASVVANG VCHLLAPLST SYIGFCVYAG
     VFGFAFGWLS SVLFET