ID   MOT2_MERUN              Reviewed;          71 AA.
AC   O35440;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Monocarboxylate transporter 2;
DE            Short=MCT 2;
DE   AltName: Full=Solute carrier family 16 member 7;
DE   Flags: Fragment;
GN   Name=SLC16A7; Synonyms=MCT2;
OS   Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Gerbillinae; Meriones.
OX   NCBI_TaxID=10047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stria vascularis;
RX   PubMed=9447934; DOI=10.1016/s0378-5955(97)00165-2;
RA   Shimozono M., Scofield M.A., Wangemann P.;
RT   "Functional evidence for a monocarboxylate transporter (MCT) in strial
RT   marginal cells and molecular evidence for MCT1 and MCT2 in stria
RT   vascularis.";
RL   Hear. Res. 114:213-222(1997).
CC   -!- FUNCTION: Proton-coupled monocarboxylate transporter. Catalyzes the
CC       rapid transport across the plasma membrane of many monocarboxylates
CC       such as lactate, pyruvate, branched-chain oxo acids derived from
CC       leucine, valine and isoleucine, and the ketone bodies acetoacetate,
CC       beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate
CC       transporter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GRID2IP (By similarity). Interacts with EMB (By
CC       similarity). Interacts with BSG (By similarity).
CC       {ECO:0000250|UniProtKB:O70451, ECO:0000250|UniProtKB:Q63344}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; AF029767; AAB84219.1; -; mRNA.
DR   AlphaFoldDB; O35440; -.
DR   SMR; O35440; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035873; P:lactate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1901475; P:pyruvate transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR027178; MCT2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11360:SF25; PTHR11360:SF25; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           <1..>71
FT                   /note="Monocarboxylate transporter 2"
FT                   /id="PRO_0000211387"
FT   TRANSMEM        <1..14
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  7864 MW;  25C82B27F22B61B1 CRC64;
     AFVDMFSRPC GGLIANTRLV RPRIQYFFSL AIVFTGVCHL LCPLAESYTA LVVYAIFFGY
     GFGSVSSILF E