MOT6_MOUSE
ID MOT6_MOUSE Reviewed; 468 AA.
AC G5E8K6; A2A9X8; A2A9X9; A2A9Y0;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Monocarboxylate transporter 6;
DE Short=MCT 6;
DE AltName: Full=Monocarboxylate transporter 5;
DE Short=MCT 5;
DE AltName: Full=Solute carrier family 16 member 5;
GN Name=Slc16a5; Synonyms=Mct5, Mct6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. Catalyzes the
CC rapid transport across the plasma membrane of many monocarboxylates
CC such as lactate, pyruvate, branched-chain oxo acids derived from
CC leucine, valine and isoleucine, and the ketone bodies acetoacetate,
CC beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM23020.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM23021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM23022.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL645470; CAM23020.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL645470; CAM23021.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL645470; CAM23022.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH466558; EDL34494.1; -; Genomic_DNA.
DR CCDS; CCDS36373.1; -.
DR RefSeq; NP_001074403.1; NM_001080934.1.
DR AlphaFoldDB; G5E8K6; -.
DR SMR; G5E8K6; -.
DR STRING; 10090.ENSMUSP00000090102; -.
DR PhosphoSitePlus; G5E8K6; -.
DR PaxDb; G5E8K6; -.
DR PRIDE; G5E8K6; -.
DR ProteomicsDB; 291387; -.
DR Antibodypedia; 46001; 33 antibodies from 12 providers.
DR Ensembl; ENSMUST00000092445; ENSMUSP00000090102; ENSMUSG00000045775.
DR GeneID; 217316; -.
DR KEGG; mmu:217316; -.
DR UCSC; uc007mhp.1; mouse.
DR CTD; 9121; -.
DR MGI; MGI:2443515; Slc16a5.
DR VEuPathDB; HostDB:ENSMUSG00000045775; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000159666; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; G5E8K6; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; G5E8K6; -.
DR TreeFam; TF313792; -.
DR BioGRID-ORCS; 217316; 7 hits in 43 CRISPR screens.
DR ChiTaRS; Slc16a5; mouse.
DR PRO; PR:G5E8K6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; G5E8K6; protein.
DR Bgee; ENSMUSG00000045775; Expressed in thymus and 55 other tissues.
DR ExpressionAtlas; G5E8K6; baseline and differential.
DR Genevisible; G5E8K6; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR030760; MCT6.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360:SF21; PTHR11360:SF21; 1.
DR Pfam; PF07690; MFS_1; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..468
FT /note="Monocarboxylate transporter 6"
FT /id="PRO_0000415804"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..171
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..330
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..396
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 429..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 51018 MW; 561A2AE11D3B60F0 CRC64;
MARALEQADG RWAWVVLLSS LVTQALTLGF PTCIGVFFTD LQRDFQASNS ETSWFPSILG
AMVHGGGPLC SILVKHFGCR VTMMLGGVLA SLGMVVSTFS GSLTHLFLTA GVITGLGMCF
SFQSSITVVG LYFVRRRPLA NALASMGLSM GVTLWPLLAR YLLETLGWRG AFLIFGGILL
HCCVCGALLR PVATNEVPEP KEDPLLPPKI PTRSCLATCV STIRYHLAFD ILRHNMGFCI
YVTGVTWMNL GFALPHIFLV PYAMHHGVDD YWAAMLMSIV GFCNIFLRPM AGLLLAGRKS
LAAYRKYLFA VAILINGLTN LICTVSADFR VLLGYCLVYS LSMCGVGILV FQVLMDIVPM
DRFPSALGLF TILCGVTSLI SPPLAGLLLD KTNNFSYVFY MSSGFLVSGS LILGVGFYAA
EKKKLKQDGQ AKMENATSEM TPMHDLTSED KDSAKKQPYP ESIYMTNV
