MOT9_HUMAN
ID MOT9_HUMAN Reviewed; 509 AA.
AC Q7RTY1; Q6ZMI2; Q9UFH8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Monocarboxylate transporter 9;
DE Short=MCT 9;
DE AltName: Full=Solute carrier family 16 member 9;
GN Name=SLC16A9; Synonyms=C10orf36, MCT9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-509.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP IDENTIFICATION.
RX PubMed=12739169; DOI=10.1007/s00424-003-1067-2;
RA Halestrap A.P., Meredith D.;
RT "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic
RT amino acid transporters and beyond.";
RL Pflugers Arch. 447:619-628(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q7RTY1; Q14240: EIF4A2; NbExp=3; IntAct=EBI-10232636, EBI-73473;
CC Q7RTY1; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-10232636, EBI-949319;
CC Q7RTY1; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-10232636, EBI-5453723;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK125791; BAC86293.1; -; mRNA.
DR EMBL; AK172758; BAD18743.1; ALT_INIT; mRNA.
DR EMBL; BC126238; AAI26239.1; -; mRNA.
DR EMBL; BC130567; AAI30568.1; -; mRNA.
DR EMBL; AL122071; CAB59247.1; -; mRNA.
DR EMBL; BN000144; CAD80155.1; -; mRNA.
DR CCDS; CCDS7256.1; -.
DR PIR; T34552; T34552.
DR RefSeq; NP_001310910.1; NM_001323981.1.
DR RefSeq; NP_919274.1; NM_194298.2.
DR RefSeq; XP_016871373.1; XM_017015884.1.
DR AlphaFoldDB; Q7RTY1; -.
DR SMR; Q7RTY1; -.
DR BioGRID; 128664; 5.
DR IntAct; Q7RTY1; 6.
DR MINT; Q7RTY1; -.
DR STRING; 9606.ENSP00000378757; -.
DR TCDB; 2.A.1.13.16; the major facilitator superfamily (mfs).
DR iPTMnet; Q7RTY1; -.
DR PhosphoSitePlus; Q7RTY1; -.
DR BioMuta; SLC16A9; -.
DR DMDM; 74723223; -.
DR EPD; Q7RTY1; -.
DR jPOST; Q7RTY1; -.
DR MassIVE; Q7RTY1; -.
DR PaxDb; Q7RTY1; -.
DR PeptideAtlas; Q7RTY1; -.
DR PRIDE; Q7RTY1; -.
DR ProteomicsDB; 68931; -.
DR Antibodypedia; 55915; 109 antibodies from 21 providers.
DR DNASU; 220963; -.
DR Ensembl; ENST00000395347.1; ENSP00000378756.1; ENSG00000165449.12.
DR Ensembl; ENST00000395348.8; ENSP00000378757.3; ENSG00000165449.12.
DR GeneID; 220963; -.
DR KEGG; hsa:220963; -.
DR MANE-Select; ENST00000395348.8; ENSP00000378757.3; NM_194298.3; NP_919274.1.
DR UCSC; uc010qig.2; human.
DR CTD; 220963; -.
DR DisGeNET; 220963; -.
DR GeneCards; SLC16A9; -.
DR HGNC; HGNC:23520; SLC16A9.
DR HPA; ENSG00000165449; Group enriched (adrenal gland, kidney).
DR neXtProt; NX_Q7RTY1; -.
DR OpenTargets; ENSG00000165449; -.
DR PharmGKB; PA134991247; -.
DR VEuPathDB; HostDB:ENSG00000165449; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000156416; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q7RTY1; -.
DR OMA; LVDIKWI; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q7RTY1; -.
DR TreeFam; TF313792; -.
DR PathwayCommons; Q7RTY1; -.
DR SignaLink; Q7RTY1; -.
DR BioGRID-ORCS; 220963; 3 hits in 1074 CRISPR screens.
DR ChiTaRS; SLC16A9; human.
DR GeneWiki; SLC16A9; -.
DR GenomeRNAi; 220963; -.
DR Pharos; Q7RTY1; Tbio.
DR PRO; PR:Q7RTY1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q7RTY1; protein.
DR Bgee; ENSG00000165449; Expressed in kidney epithelium and 139 other tissues.
DR Genevisible; Q7RTY1; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015226; F:carnitine transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0005308; F:creatine transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:1902603; P:carnitine transmembrane transport; IDA:UniProtKB.
DR GO; GO:0015881; P:creatine transmembrane transport; IDA:UniProtKB.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR GO; GO:0046415; P:urate metabolic process; IMP:BHF-UCL.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR030767; MCT9.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360:SF158; PTHR11360:SF158; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..509
FT /note="Monocarboxylate transporter 9"
FT /id="PRO_0000289332"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 203
FT /note="A -> V (in dbSNP:rs56370926)"
FT /id="VAR_062149"
FT VARIANT 258
FT /note="T -> K (in dbSNP:rs2242206)"
FT /id="VAR_032619"
FT VARIANT 461
FT /note="D -> E (in dbSNP:rs11006655)"
FT /id="VAR_032620"
SQ SEQUENCE 509 AA; 55794 MW; 716D56D969B1B0A8 CRC64;
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK TAWVGSLASG
VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP NIYFLFFSYG IVVGLGCGLL
YTATVTITCQ YFDDRRGLAL GLISTGSSVG LFIYAALQRM LVEFYGLDGC LLIVGALALN
ILACGSLMRP LQSSDCPLPK KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI
TLANGDWKQD SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG IMTAVGKLLL
GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL LSGILGFLTG NWSIFPYVTT
KTVGIEKLAH AYGILMFFAG LGNSLGPPIV GWFYDWTQTY DIAFYFSGFC VLLGGFILLL
AALPSWDTCN KQLPKPAPTT FLYKVASNV
