MOT9_MOUSE
ID MOT9_MOUSE Reviewed; 508 AA.
AC Q7TM99; Q0P652;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Monocarboxylate transporter 9;
DE Short=MCT 9;
DE AltName: Full=Solute carrier family 16 member 9;
GN Name=Slc16a9; Synonyms=Mct9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34205.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK004556; BAB23369.2; -; mRNA.
DR EMBL; AK004599; BAB23400.2; -; mRNA.
DR EMBL; AK004684; BAB23471.2; -; mRNA.
DR EMBL; BC034205; AAH34205.1; ALT_FRAME; mRNA.
DR EMBL; BC055839; AAH55839.1; -; mRNA.
DR CCDS; CCDS23913.1; -.
DR RefSeq; NP_080083.2; NM_025807.3.
DR RefSeq; XP_006514023.1; XM_006513960.3.
DR AlphaFoldDB; Q7TM99; -.
DR SMR; Q7TM99; -.
DR BioGRID; 211767; 1.
DR STRING; 10090.ENSMUSP00000047912; -.
DR iPTMnet; Q7TM99; -.
DR PhosphoSitePlus; Q7TM99; -.
DR MaxQB; Q7TM99; -.
DR PaxDb; Q7TM99; -.
DR PRIDE; Q7TM99; -.
DR ProteomicsDB; 290283; -.
DR Antibodypedia; 55915; 109 antibodies from 21 providers.
DR DNASU; 66859; -.
DR Ensembl; ENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
DR GeneID; 66859; -.
DR KEGG; mmu:66859; -.
DR UCSC; uc007fnq.1; mouse.
DR CTD; 220963; -.
DR MGI; MGI:1914109; Slc16a9.
DR VEuPathDB; HostDB:ENSMUSG00000037762; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000156416; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q7TM99; -.
DR OMA; LVDIKWI; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q7TM99; -.
DR TreeFam; TF313792; -.
DR BioGRID-ORCS; 66859; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Slc16a9; mouse.
DR PRO; PR:Q7TM99; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q7TM99; protein.
DR Bgee; ENSMUSG00000037762; Expressed in pigmented layer of retina and 187 other tissues.
DR Genevisible; Q7TM99; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0015226; F:carnitine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005308; F:creatine transmembrane transporter activity; ISO:MGI.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:1902603; P:carnitine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0015881; P:creatine transmembrane transport; ISO:MGI.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR GO; GO:0046415; P:urate metabolic process; ISO:MGI.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR030767; MCT9.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360:SF158; PTHR11360:SF158; 1.
DR Pfam; PF07690; MFS_1; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..508
FT /note="Monocarboxylate transporter 9"
FT /id="PRO_0000289333"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..508
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 508 AA; 55757 MW; EB86866D96B46AB6 CRC64;
MEFQKSPDGG WGWVIVVVSF FTQFLSYGSP LAVGVLYVEW LDAFGEGKGK TAWVGSLASG
VGLLASPVCS LFVSSFGARP VTIFSGFLVA GGLMLSSLAP NIYFLFFSYG IVVGLGCGLL
YTATVTITCQ YFDSRRGLAL GLISTGSSVG LFIYAALQRM LIEFYGLDGC LLIVGALALN
ILACGSLMRP LQTSDCPFPE KTAPENVPDR YSMYNEKEKN PEETMNFQDK GYSSEDKCLP
NGDWGRETSL PKSLAIAAHT KEPETYKKKV VEQTNFCKQL AKRKWQLYRN YCGETASLFK
NKVFSALFIA ILLFDIGGFP PSLLMEDVAR SYHVREEDLT MPLISIFGIM TAVGKLLLGI
LADFKWINTL YLYVATLIIT GLALCAIPFA KSYVTLAILS GILGFLTGNW SIFPYVTTKT
VGIDKLAHAY GILMFFAGLG NSLGPPIVGW FYDWTQTYDI AFYFSGFCVL LGGFILLLAI
LPCWDMCNKK LPKPAVPTTF FYKVASNV
