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MOT9_PONAB
ID   MOT9_PONAB              Reviewed;         509 AA.
AC   Q5R5M4; Q5R5G5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Monocarboxylate transporter 9;
DE            Short=MCT 9;
DE   AltName: Full=Solute carrier family 16 member 9;
GN   Name=SLC16A9; Synonyms=MCT9;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC       transport of monocarboxylates across the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; CR860833; CAH92942.1; -; mRNA.
DR   EMBL; CR860895; CAH93001.1; -; mRNA.
DR   RefSeq; NP_001126733.1; NM_001133261.1.
DR   AlphaFoldDB; Q5R5M4; -.
DR   SMR; Q5R5M4; -.
DR   STRING; 9601.ENSPPYP00000002813; -.
DR   GeneID; 100173735; -.
DR   KEGG; pon:100173735; -.
DR   CTD; 220963; -.
DR   eggNOG; KOG2504; Eukaryota.
DR   InParanoid; Q5R5M4; -.
DR   OrthoDB; 916876at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015226; F:carnitine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:1902603; P:carnitine transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR030767; MCT9.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11360:SF158; PTHR11360:SF158; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..509
FT                   /note="Monocarboxylate transporter 9"
FT                   /id="PRO_0000289334"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        483..509
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        461
FT                   /note="E -> G (in Ref. 1; CAH93001)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   509 AA;  55829 MW;  C265CED0E1DF0D29 CRC64;
     MELKKSPDGG WGWVIVFVSF FTQFLCYGSP LAVGVLYIEW LDAFGEGKGK TAWVGSLASG
     VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP NIYFLFFSYG IVVGLGCGLL
     YTATVTITCL YFDDRRGLAL GLISTGSSVG LFIYAALQRM LVEFYGLDGC LLIVGALALN
     ILACGSLMRP LQSSDCPLPK KIAPEDLPDK YSIYNEKGKN LEENINILEK SYSSEEKCRT
     TLANGDWKQD SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
     FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG IMTAVGKLLL
     GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL LSGILGFLTG NWSIFPYVTT
     KTVGIEKLAH AYGILMFFAG LGNSLGPPIV GWFYDWTQTY EIAFYFSGFC VLLGGFILLL
     AALPSWDTCN KQLPKPAPTT FLYKVASNV
 
 
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