ID   6PGL_PSEAE              Reviewed;         238 AA.
AC   Q9X2N2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=pgl; Synonyms=devB; OrderedLocusNames=PA3182;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RA   Hager P.W., Dail M.B., Phibbs P.V. Jr.;
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD22666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF029673; AAD22666.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE004091; AAG06570.1; -; Genomic_DNA.
DR   PIR; H83247; H83247.
DR   RefSeq; NP_251872.1; NC_002516.2.
DR   RefSeq; WP_003113441.1; NZ_QZGE01000023.1.
DR   AlphaFoldDB; Q9X2N2; -.
DR   SMR; Q9X2N2; -.
DR   STRING; 287.DR97_4754; -.
DR   PaxDb; Q9X2N2; -.
DR   PRIDE; Q9X2N2; -.
DR   DNASU; 882680; -.
DR   EnsemblBacteria; AAG06570; AAG06570; PA3182.
DR   GeneID; 882680; -.
DR   KEGG; pae:PA3182; -.
DR   PATRIC; fig|208964.12.peg.3326; -.
DR   PseudoCAP; PA3182; -.
DR   HOGENOM; CLU_053947_2_1_6; -.
DR   InParanoid; Q9X2N2; -.
DR   OMA; YQLFEFE; -.
DR   PhylomeDB; Q9X2N2; -.
DR   BioCyc; PAER208964:G1FZ6-3242-MON; -.
DR   BRENDA; 3.1.1.31; 5087.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..238
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000090102"
SQ   SEQUENCE   238 AA;  25571 MW;  EECE335BBE904F46 CRC64;
     MAISELKLPA GVGLQVWGSA AEQARGLAAE VAGRLRSALA EQGQALLVVS GGRSPVAFLE
     ALSEEPLDWS RITVSLADER WVPESHADSN AGLVRRHLLR GEAAKARFIG LYQPAASLEE
     AAELADHHLH ELPLPIDVLV LGMGDDGHTA SLFPNSPGLD LAMDPQGTRR CLPMWAPSVP
     HQRLTLPRAV LAAAKVQLLA IQGQSKLATL NAALAVEDER RMPVRAFLRA PLTIHWYP