MOTA_BACSU
ID MOTA_BACSU Reviewed; 270 AA.
AC P28611;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Motility protein A;
DE AltName: Full=Chemotaxis protein MotA;
GN Name=motA; OrderedLocusNames=BSU13690;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1624413; DOI=10.1128/jb.174.13.4197-4204.1992;
RA Mirel D.B., Lustre V.M., Chamberlin M.J.;
RT "An operon of Bacillus subtilis motility genes transcribed by the sigma D
RT form of RNA polymerase.";
RL J. Bacteriol. 174:4197-4204(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: MotA and MotB comprise the stator element of the flagellar
CC motor complex. Required for rotation of the flagellar motor. Probable
CC transmembrane proton channel (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Each stator complex is composed of 4 MotA and 2 MotB subunits.
CC 2 A subunits and 1 B subunit are thought to form a single ion channel,
CC so that each stator complex contains two channels (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MotA family. {ECO:0000305}.
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DR EMBL; M77238; AAA22602.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13242.1; -; Genomic_DNA.
DR PIR; A42882; A42882.
DR RefSeq; NP_389252.1; NC_000964.3.
DR RefSeq; WP_003244739.1; NZ_JNCM01000035.1.
DR PDB; 6YSL; EM; 3.50 A; C/D/E/F/G=1-270.
DR PDBsum; 6YSL; -.
DR AlphaFoldDB; P28611; -.
DR SMR; P28611; -.
DR IntAct; P28611; 1.
DR STRING; 224308.BSU13690; -.
DR TCDB; 1.A.30.1.3; the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.
DR jPOST; P28611; -.
DR PaxDb; P28611; -.
DR PRIDE; P28611; -.
DR EnsemblBacteria; CAB13242; CAB13242; BSU_13690.
DR GeneID; 939302; -.
DR KEGG; bsu:BSU13690; -.
DR PATRIC; fig|224308.179.peg.1486; -.
DR eggNOG; COG1291; Bacteria.
DR InParanoid; P28611; -.
DR OMA; EIETHHQ; -.
DR PhylomeDB; P28611; -.
DR BioCyc; BSUB:BSU13690-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR000540; Flag_MotA_CS.
DR InterPro; IPR002898; MotA_ExbB_proton_chnl.
DR Pfam; PF01618; MotA_ExbB; 1.
DR PROSITE; PS01307; MOTA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Chemotaxis; Flagellar rotation;
KW Hydrogen ion transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..270
FT /note="Motility protein A"
FT /id="PRO_0000189570"
FT TRANSMEM 4..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT HELIX 4..23
FT /evidence="ECO:0007829|PDB:6YSL"
FT TURN 29..31
FT /evidence="ECO:0007829|PDB:6YSL"
FT TURN 36..39
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 40..50
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 55..58
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 59..63
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 66..68
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 75..78
FT /evidence="ECO:0007829|PDB:6YSL"
FT TURN 79..81
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 82..84
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 85..92
FT /evidence="ECO:0007829|PDB:6YSL"
FT TURN 98..101
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 107..116
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 123..169
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 170..172
FT /evidence="ECO:0007829|PDB:6YSL"
FT STRAND 175..177
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 178..198
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 201..231
FT /evidence="ECO:0007829|PDB:6YSL"
FT TURN 235..237
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 239..242
FT /evidence="ECO:0007829|PDB:6YSL"
FT HELIX 248..251
FT /evidence="ECO:0007829|PDB:6YSL"
SQ SEQUENCE 270 AA; 29339 MW; 81CF32526BB43C41 CRC64;
MDKTSLIGII LAFVALSVGM VLKGVSFSAL ANPAAILIII AGTISAVVIA FPTKEIKKVP
TLFRVLFKEN KQLTIEELIP MFSEWAQLAR REGLLALEAS IEDVDDAFLK NGLSMAVDGQ
SAEFIRDIMT EEVEAMEDRH QAGAAIFTQA GTYAPTLGVL GAVIGLIAAL SHMDNTDELG
HAISAAFVAT LLGIFTGYVL WHPFANKLKR KSKQEVKLRE VMIEGVLSVL EGQAPKVIEQ
KLLMYLPAKD RLKFAEQGEA QNGEKKEEEA
