ID   MOTI_CANLF              Reviewed;          22 AA.
AC   P19863; Q4L0E5;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Motilin;
GN   Name=MLN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Intestine;
RX   PubMed=6844663; DOI=10.1016/0167-0115(83)90251-3;
RA   Poitras P., Reeve J.R. Jr., Hunkapiller M.W., Hood L.E., Walsh J.H.;
RT   "Purification and characterization of canine intestinal motilin.";
RL   Regul. Pept. 5:197-208(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oh H., Huh C., Baek Y.;
RT   "Canis familiaris motilin mRNA, partial sequence (mature motilin).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   EMBL; AY651885; AAT72899.1; -; mRNA.
DR   PIR; S00189; S00189.
DR   AlphaFoldDB; P19863; -.
DR   STRING; 9615.ENSCAFP00000056335; -.
DR   PaxDb; P19863; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Motilin"
FT                   /id="PRO_0000044065"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   UNSURE          1
SQ   SEQUENCE   22 AA;  2685 MW;  4BECB840ABE0639F CRC64;
     FVPIFTHSEL QKIREKERNK GQ