ID   MOTI_CHICK              Reviewed;          22 AA.
AC   Q9PRP6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Motilin;
GN   Name=MLN;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Small intestine;
RX   PubMed=8801522; DOI=10.1016/0196-9781(95)02120-5;
RA   De Clercq P., Depoortere I., Macielag M., Vandermeers A.,
RA   Vandermeers-Piret M.C., Peeters T.L.;
RT   "Isolation, sequence, and bioactivity of chicken motilin.";
RL   Peptides 17:203-208(1996).
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9PRP6; -.
DR   STRING; 9031.ENSGALP00000034399; -.
DR   PaxDb; Q9PRP6; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   HOGENOM; CLU_154278_0_0_1; -.
DR   OrthoDB; 1512819at2759; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006939; P:smooth muscle contraction; IDA:AgBase.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Motilin"
FT                   /id="PRO_0000044066"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   22 AA;  2686 MW;  6FD6A79B7FB02680 CRC64;
     FVPFFTQSDI QKMQEKERNK GQ