ID   MOTI_FELCA              Reviewed;         116 AA.
AC   Q9XSE2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Promotilin;
DE   Contains:
DE     RecName: Full=Motilin;
DE   Contains:
DE     RecName: Full=Motilin-associated peptide;
DE              Short=MAP;
DE   Flags: Precursor;
GN   Name=MLN;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Duodenal mucosa;
RA   Huang Z., Depoortere I., Peeters T.L.;
RT   "cDNA encoding prepromotilin from cat duodenum mucosa.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   EMBL; AF127917; AAD33347.1; -; mRNA.
DR   RefSeq; NP_001009278.1; NM_001009278.1.
DR   AlphaFoldDB; Q9XSE2; -.
DR   SMR; Q9XSE2; -.
DR   STRING; 9685.ENSFCAP00000004890; -.
DR   GeneID; 493834; -.
DR   KEGG; fca:493834; -.
DR   CTD; 4295; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   InParanoid; Q9XSE2; -.
DR   OrthoDB; 1512819at2759; -.
DR   TreeFam; TF336217; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031788; F:motilin receptor binding; IBA:GO_Central.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   InterPro; IPR015662; Promotilin.
DR   PANTHER; PTHR14156; PTHR14156; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..116
FT                   /note="Promotilin"
FT                   /id="PRO_0000342169"
FT   PEPTIDE         26..47
FT                   /note="Motilin"
FT                   /id="PRO_0000019180"
FT   PEPTIDE         50..116
FT                   /note="Motilin-associated peptide"
FT                   /id="PRO_0000019181"
FT   REGION          39..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   116 AA;  13056 MW;  E60FBFB6303E685E CRC64;
     MVSRKAVAVL LMVHVAVMLA SQTEAFVPIF THSELQRIRE KERNKGQKKS LIVQQRSEEV
     GPLDPVEPPE EEENEVIKLT APVAIGTRMN SRQLEKYRAA LEGLLSEVLL PARNDK