ID   MOTI_HORSE              Reviewed;          92 AA.
AC   O46617;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Promotilin;
DE   Contains:
DE     RecName: Full=Motilin;
DE   Contains:
DE     RecName: Full=Motilin-associated peptide;
DE              Short=MAP;
DE   Flags: Precursor; Fragment;
GN   Name=MLN;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Duodenal mucosa;
RX   PubMed=10564829; DOI=10.1016/s0378-1119(99)00397-2;
RA   Huang Z., Depoortere I., De Clercq P., Peeters T.;
RT   "Sequence and characterization of cDNA encoding the motilin precursor from
RT   chicken, dog, cow and horse. Evidence of mosaic evolution in
RT   prepromotilin.";
RL   Gene 240:217-226(1999).
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   EMBL; AF047520; AAC03790.1; -; mRNA.
DR   AlphaFoldDB; O46617; -.
DR   STRING; 9796.ENSECAP00000011760; -.
DR   InParanoid; O46617; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031788; F:motilin receptor binding; IBA:GO_Central.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   InterPro; IPR015662; Promotilin.
DR   PANTHER; PTHR14156; PTHR14156; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted.
FT   CHAIN           1..92
FT                   /note="Promotilin"
FT                   /id="PRO_0000342170"
FT   PEPTIDE         1..22
FT                   /note="Motilin"
FT                   /id="PRO_0000019182"
FT   PEPTIDE         25..92
FT                   /note="Motilin-associated peptide"
FT                   /id="PRO_0000019183"
FT   REGION          12..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   92 AA;  10410 MW;  99DBCA503EAFE4C8 CRC64;
     FVPIFTYSEL QRMQEKERNR GQKKSLGLQQ RSEEVGSLDP TEAAEEEGKE VIKLTAPVEI
     GMRMNSRQLE KYRAALEGLL SEVLLSTQNA AK