ID   MOTI_MACMU              Reviewed;         115 AA.
AC   O18811;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Promotilin;
DE   Contains:
DE     RecName: Full=Motilin;
DE   Contains:
DE     RecName: Full=Motilin-associated peptide;
DE              Short=MAP;
DE   Flags: Precursor;
GN   Name=MLN;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=9762897; DOI=10.1016/s0014-5793(98)01056-4;
RA   Huang Z., De Clercq P., Depoortere I., Peeters T.L.;
RT   "Isolation and sequence of cDNA encoding the motilin precursor from monkey
RT   intestine. Demonstration of the motilin precursor in the monkey brain.";
RL   FEBS Lett. 435:149-152(1998).
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF016372; AAC82510.1; -; mRNA.
DR   RefSeq; NP_001027979.1; NM_001032807.2.
DR   AlphaFoldDB; O18811; -.
DR   STRING; 9544.ENSMMUP00000028628; -.
DR   GeneID; 574099; -.
DR   KEGG; mcc:574099; -.
DR   CTD; 4295; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   InParanoid; O18811; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   InterPro; IPR015662; Promotilin.
DR   PANTHER; PTHR14156; PTHR14156; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..115
FT                   /note="Promotilin"
FT                   /id="PRO_0000342172"
FT   PEPTIDE         26..47
FT                   /note="Motilin"
FT                   /id="PRO_0000019186"
FT   PEPTIDE         50..115
FT                   /note="Motilin-associated peptide"
FT                   /id="PRO_0000019187"
FT   REGION          40..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  12821 MW;  FB67E1080E989159 CRC64;
     MVSRKAVAAL LVVHAPAMLA SQTEAFVPIF TYGELQRMQE KERSKGQKKS LSVWQRSGEE
     GPVDPAEPIE EEGNEMIKLT APLEIGMRMN SRQLEKYRAA LEGLLSEMLP QHAAK