ID   MOTI_RABIT              Reviewed;         133 AA.
AC   P27114;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Promotilin;
DE   Contains:
DE     RecName: Full=Motilin;
DE   Contains:
DE     RecName: Full=Motilin-associated peptide;
DE              Short=MAP;
DE   Flags: Precursor;
GN   Name=MLN;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1627652; DOI=10.1016/0167-4781(92)90038-2;
RA   Banfield D.K., Macgillivray R.T.A., Brown J.C., McIntosh C.H.S.;
RT   "The isolation and characterization of rabbit motilin precursor cDNA.";
RL   Biochim. Biophys. Acta 1131:341-344(1992).
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   EMBL; X63860; CAA45342.1; -; mRNA.
DR   PIR; S24315; S24315.
DR   RefSeq; NP_001095169.1; NM_001101699.1.
DR   AlphaFoldDB; P27114; -.
DR   SMR; P27114; -.
DR   STRING; 9986.ENSOCUP00000005032; -.
DR   BindingDB; P27114; -.
DR   GeneID; 100009276; -.
DR   KEGG; ocu:100009276; -.
DR   CTD; 4295; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   InParanoid; P27114; -.
DR   OrthoDB; 1512819at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   InterPro; IPR015662; Promotilin.
DR   PANTHER; PTHR14156; PTHR14156; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT   CHAIN           26..133
FT                   /note="Promotilin"
FT                   /id="PRO_0000342174"
FT   PEPTIDE         26..47
FT                   /note="Motilin"
FT                   /id="PRO_0000019190"
FT   PEPTIDE         50..133
FT                   /note="Motilin-associated peptide"
FT                   /id="PRO_0000019191"
FT   REGION          38..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  14667 MW;  878195E28D45AAC0 CRC64;
     MVSRKAVAAL LLVHVTAMLA SQTEAFVPIF TYSELQRMQE RERNRGHKKS LSVQQRSDAA
     AAPRPAEPTL EEENGRMQLT APVEIGMRMN SRQLEKYRAA LEAAERAVHP DAPSRPCWPA
     GGESGWSGEP SPT