ID   MOTI_SHEEP              Reviewed;         115 AA.
AC   O18845;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Promotilin;
DE   Contains:
DE     RecName: Full=Motilin;
DE   Contains:
DE     RecName: Full=Motilin-associated peptide;
DE              Short=MAP;
DE   Flags: Precursor;
GN   Name=MLN;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=9427564; DOI=10.1016/s0378-1119(97)00494-0;
RA   De Clercq P., Depoortere I., Peeters T.L.;
RT   "Isolation and sequencing of the cDNA encoding the motilin precursor from
RT   sheep intestine.";
RL   Gene 202:187-191(1997).
CC   -!- FUNCTION: Plays an important role in the regulation of interdigestive
CC       gastrointestinal motility and indirectly causes rhythmic contraction of
CC       duodenal and colonic smooth muscle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family. {ECO:0000305}.
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DR   EMBL; AF022771; AAB80930.1; -; mRNA.
DR   PIR; JC6511; JC6511.
DR   RefSeq; NP_001009439.1; NM_001009439.1.
DR   AlphaFoldDB; O18845; -.
DR   STRING; 9940.ENSOARP00000011236; -.
DR   GeneID; 443473; -.
DR   KEGG; oas:443473; -.
DR   CTD; 4295; -.
DR   eggNOG; ENOG502SS7F; Eukaryota.
DR   OrthoDB; 1512819at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   InterPro; IPR015662; Promotilin.
DR   PANTHER; PTHR14156; PTHR14156; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..115
FT                   /note="Promotilin"
FT                   /id="PRO_0000342175"
FT   PEPTIDE         26..47
FT                   /note="Motilin"
FT                   /id="PRO_0000019192"
FT   PEPTIDE         50..115
FT                   /note="Motilin-associated peptide"
FT                   /id="PRO_0000019193"
FT   REGION          43..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  12956 MW;  383892C2AD7EC5ED CRC64;
     MLSRKATAIL LVVHAAAMLA SQTEGFVPIF TYGEVQRMQE KERYKGQKKS LSVQQRSEEV
     GPVDPAEPRE EKQEVIKLTA PVEIGMRMNS RQLEKYQATL EGLLRKALPS SRNAQ