ID   MOXR_METEA              Reviewed;         343 AA.
AC   P30621; C5AQA5;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein MoxR;
DE   AltName: Full=Protein MxaR;
GN   Name=moxR; Synonyms=mxaR; OrderedLocusNames=MexAM1_META1p4534;
OS   Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS   9133 / AM1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=272630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8997703; DOI=10.1111/j.1574-6968.1997.tb10167.x;
RA   Amaratunga K., Goodwin P.M., O'Connor C.D., Anthony C.;
RT   "The methanol oxidation genes mxaFJGIR (S) ACKLD in Methylobacterium
RT   extorquens.";
RL   FEMS Microbiol. Lett. 146:31-38(1997).
RN   [2]
RP   ERRATUM OF PUBMED:8997703.
RX   PubMed=9163922; DOI=10.1016/s0378-1097(97)00091-8;
RA   Amaratunga K., Goodwin P.M., O'Connor C.D., Anthony C.;
RL   FEMS Microbiol. Lett. 150:175-177(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1;
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.
RX   PubMed=2504152; DOI=10.1042/bj2600857;
RA   Nunn D.N., Day D., Anthony C.;
RT   "The second subunit of methanol dehydrogenase of Methylobacterium
RT   extorquens AM1.";
RL   Biochem. J. 260:857-862(1989).
CC   -!- FUNCTION: May be involved in the regulation of formation of active
CC       methanol dehydrogenase.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MoxR family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y07864; CAA69191.1; -; Genomic_DNA.
DR   EMBL; CP001510; ACS42165.1; -; Genomic_DNA.
DR   EMBL; X15792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_003599122.1; NC_012808.1.
DR   AlphaFoldDB; P30621; -.
DR   SMR; P30621; -.
DR   STRING; 272630.MexAM1_META1p4534; -.
DR   EnsemblBacteria; ACS42165; ACS42165; MexAM1_META1p4534.
DR   KEGG; mea:Mex_1p4534; -.
DR   eggNOG; COG0714; Bacteria.
DR   HOGENOM; CLU_034716_0_1_5; -.
DR   OMA; PVYEMRR; -.
DR   OrthoDB; 688156at2; -.
DR   Proteomes; UP000009081; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0015945; P:methanol metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011703; ATPase_AAA-3.
DR   InterPro; IPR041628; ChlI/MoxR_AAA_lid.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07726; AAA_3; 1.
DR   Pfam; PF17863; AAA_lid_2; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Methanol utilization; Nucleotide-binding.
FT   CHAIN           1..343
FT                   /note="Protein MoxR"
FT                   /id="PRO_0000096543"
FT   BINDING         53..60
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        192
FT                   /note="Missing (in Ref. 1; CAA69191)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255..265
FT                   /note="GPAGIRLPGIA -> APPHPLARHR (in Ref. 1; CAA69191)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        327
FT                   /note="Q -> E (in Ref. 1; CAA69191)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   343 AA;  38614 MW;  7019BABA2856D94F CRC64;
     MNTLRPGDAM LTDWRDAAAR FEREIAKAVV GQDRAIRLLT IAIFARGHVM LEGDVGVGKT
     TLLRAVARGL GGAYERVEGT VDMMPTDLIY HTYLGEDGRP RVEPGPVLRR AEDLSVFFFN
     EINRARPQVH ALLLRIMAER SVSAFNREYR FPNLQVFADR NRVEREETFE LPAAARDRFL
     MEIGMEAPRD ARARRDLVFD PRFHDTDRLT EEVEAGVLDF ERIGTIASAI QHAISAEPAI
     EAYVVGLWEA LVRPGPAGIR LPGIAMDRLV QGGASPRGVA FLVRAARVRA WLEGRDWLVP
     EDIRAVFPEV MAHRVFLEPV YEMRRAQIVP DLIRAVFETV PAP