ID   MOXX_PARDE              Reviewed;         223 AA.
AC   P29904;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Methanol utilization control regulatory protein MoxX;
GN   Name=moxX;
OS   Paracoccus denitrificans.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=266;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8392137; DOI=10.1111/j.1365-2958.1993.tb01590.x;
RA   Harms N., Reijnders W.N., Anazawa H., de Palen C.J., van Spanning R.J.M.,
RA   Oltmann L.F., Stouthamer A.H.;
RT   "Identification of a two-component regulatory system controlling methanol
RT   dehydrogenase synthesis in Paracoccus denitrificans.";
RL   Mol. Microbiol. 8:457-470(1993).
CC   -!- FUNCTION: Member of the two-component regulatory system MoxY/MoxX
CC       probably involved in the regulation of the methanol dehydrogenase
CC       expression.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by MoxY. {ECO:0000305}.
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DR   EMBL; M92421; AAC36998.1; -; Unassigned_DNA.
DR   PIR; S32872; S32872.
DR   RefSeq; WP_011749262.1; NZ_FOYK01000012.1.
DR   AlphaFoldDB; P29904; -.
DR   SMR; P29904; -.
DR   PRIDE; P29904; -.
DR   OMA; DHQVVRR; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015945; P:methanol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Cytoplasm; DNA-binding; Methanol utilization; Phosphoprotein;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..223
FT                   /note="Methanol utilization control regulatory protein
FT                   MoxX"
FT                   /id="PRO_0000081139"
FT   DOMAIN          16..133
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          155..220
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        179..198
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   223 AA;  24450 MW;  D5DB8ACCA909CC45 CRC64;
     MQAALKLQSD DARPLQILIV DDHPVVAEGW GRIIRTKTAC EIASAPSASE GWRAWRQARP
     DLMVVDLSIG RNKIAGIRLI ERLRRVDPDL PILVFTMHRS PVLARRALMF GANGIINKDS
     PPAEICAAFT EVARGGNYVD SRLAMQIALL NVSRPGTSAP RLTGREEEIL GMITEGMSYR
     DIADRACISY KTVSNVSLVL KDKLGAANLA DLVVKGIRYF EGD