ID   MOXY_PARDE              Reviewed;         446 AA.
AC   P29905;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Methanol utilization control sensor protein MoxY;
DE            EC=2.7.3.-;
GN   Name=moxY;
OS   Paracoccus denitrificans.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=266;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8392137; DOI=10.1111/j.1365-2958.1993.tb01590.x;
RA   Harms N., Reijnders W.N., Anazawa H., de Palen C.J., van Spanning R.J.M.,
RA   Oltmann L.F., Stouthamer A.H.;
RT   "Identification of a two-component regulatory system controlling methanol
RT   dehydrogenase synthesis in Paracoccus denitrificans.";
RL   Mol. Microbiol. 8:457-470(1993).
CC   -!- FUNCTION: Member of the two-component regulatory system MoxY/MoxX
CC       probably involved in the regulation of the methanol dehydrogenase
CC       expression. May function as a membrane-associated protein kinase that
CC       phosphorylates MoxX in response to environmental signals.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
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DR   EMBL; M92421; AAC36997.1; -; Unassigned_DNA.
DR   PIR; S32871; S32871.
DR   AlphaFoldDB; P29905; -.
DR   SMR; P29905; -.
DR   BRENDA; 2.7.13.3; 3341.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0015945; P:methanol metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032244; LapD_MoxY_N.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   Pfam; PF16448; LapD_MoxY_N; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Kinase; Membrane; Methanol utilization;
KW   Phosphoprotein; Transferase; Transmembrane; Transmembrane helix;
KW   Two-component regulatory system.
FT   CHAIN           1..446
FT                   /note="Methanol utilization control sensor protein MoxY"
FT                   /id="PRO_0000074805"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          167..219
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   REGION          390..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  48236 MW;  B3CE724D61E60ECB CRC64;
     MGLACAVSLS LCLIVSAILI VNARQAVQEE TESAFRLAHE AVVRRLPPSH GGRDTMTEAI
     GLAEEIDGLR HVSARILDPE GQPLQHRAHG QLRSEASAPQ WFSALMTPPL VEALVPITHY
     PNVLGMLRVA ADPTDEIAEV WGDFSIILPV LFLAGLAMVG LAFLMTTLLT RRLQSVQAAM
     AQMQDGRLSV RAPDDRLTEF ADLAAGVNAL ASHLQAEQAE NDLLQARLIG SSEAERSRIA
     LDLHDEMGPQ LFALRAAVSH AQAMTADLPE RPAALDETLD AIAGHALEVQ RSARTAINDL
     RPMLLGEASL AELLAELVTG FRDVASETRV VLDVDPEVEG SSPGELAELS IYRFARESVL
     NAMRHGRATV VRVSLDTMPD EPGQIVVRVT DNGKGPQSGT GRPTPGFGQI GIEDRARALG
     ATYLPPWRDN RLTHTELRMP RPCKLR