ID   MP17L_BOVIN             Reviewed;         196 AA.
AC   Q2KIK2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Mpv17-like protein;
DE   AltName: Full=M-LP homolog;
DE            Short=M-LPH;
GN   Name=MPV17L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in reactive oxygen species metabolism by up- or
CC       down-regulation of the genes of antioxidant enzymes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC112608; AAI12609.1; -; mRNA.
DR   RefSeq; NP_001040067.1; NM_001046602.2.
DR   AlphaFoldDB; Q2KIK2; -.
DR   STRING; 9913.ENSBTAP00000056473; -.
DR   PaxDb; Q2KIK2; -.
DR   GeneID; 617491; -.
DR   KEGG; bta:617491; -.
DR   CTD; 255027; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   InParanoid; Q2KIK2; -.
DR   OrthoDB; 1301408at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..196
FT                   /note="Mpv17-like protein"
FT                   /id="PRO_0000333177"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT   TRANSMEM        17..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..50
FT                   /note="Lumenal"
FT   TRANSMEM        51..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..90
FT                   /note="Cytoplasmic"
FT   TRANSMEM        91..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..150
FT                   /note="Lumenal"
FT   TRANSMEM        151..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..196
FT                   /note="Cytoplasmic"
FT   REGION          16..55
FT                   /note="Targeting to peroxisomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  22328 MW;  BBB538DAD8A58DE7 CRC64;
     MVSWWQALTR AAGRYPWPAN VLLYAGFFSG GDALQQVLRG GPADWQHTRH VATVAVAFHA
     NLNYVWLNLL ERALPGRAPR TILAKVLCDQ ALGGPVYVST FYAGMSILQG KDDIFLDMRQ
     KFWNTYKSGL MYWPFVQLIN FSLIPIRWRT AYTGLCGFLW ATFLCFSQQE GDGTFKSAFT
     FRRIKVTNEV EKPSEK