MP20_DROME
ID MP20_DROME Reviewed; 184 AA.
AC P14318; A4UZF7; Q1WWC7; Q9V6M7;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Muscle-specific protein 20;
GN Name=Mp20; Synonyms=Tpn; ORFNames=CG4696;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Muscle;
RX PubMed=2537318; DOI=10.1083/jcb.108.2.521;
RA Ayme-Southgate A., Lasko P., French C., Pardue M.L.;
RT "Characterization of the gene for mp20: a Drosophila muscle protein that is
RT not found in asynchronous oscillatory flight muscle.";
RL J. Cell Biol. 108:521-531(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- TISSUE SPECIFICITY: Found in synchronous muscle; not found in
CC asynchronous indirect flight muscle. {ECO:0000269|PubMed:2537318}.
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABE01209.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y00795; CAA68746.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF58396.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68603.1; -; Genomic_DNA.
DR EMBL; AY071496; AAL49118.1; -; mRNA.
DR EMBL; BT024979; ABE01209.1; ALT_INIT; mRNA.
DR PIR; A30128; A30128.
DR RefSeq; NP_001014522.2; NM_001014522.2.
DR RefSeq; NP_476643.1; NM_057295.4.
DR AlphaFoldDB; P14318; -.
DR SMR; P14318; -.
DR BioGRID; 62231; 8.
DR DIP; DIP-18096N; -.
DR IntAct; P14318; 3.
DR STRING; 7227.FBpp0086858; -.
DR PaxDb; P14318; -.
DR PRIDE; P14318; -.
DR DNASU; 36468; -.
DR EnsemblMetazoa; FBtr0087745; FBpp0086858; FBgn0002789.
DR GeneID; 36468; -.
DR KEGG; dme:Dmel_CG4696; -.
DR CTD; 36468; -.
DR FlyBase; FBgn0002789; Mp20.
DR VEuPathDB; VectorBase:FBgn0002789; -.
DR eggNOG; KOG2046; Eukaryota.
DR GeneTree; ENSGT00940000170006; -.
DR HOGENOM; CLU_055232_1_1_1; -.
DR InParanoid; P14318; -.
DR OMA; EYGYMKG; -.
DR OrthoDB; 861989at2759; -.
DR PhylomeDB; P14318; -.
DR SignaLink; P14318; -.
DR BioGRID-ORCS; 36468; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Mp20; fly.
DR GenomeRNAi; 36468; -.
DR PRO; PR:P14318; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0002789; Expressed in oviduct (Drosophila) and 31 other tissues.
DR Genevisible; P14318; DM.
DR GO; GO:0005737; C:cytoplasm; HDA:FlyBase.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0007520; P:myoblast fusion; IMP:FlyBase.
DR GO; GO:1901739; P:regulation of myoblast fusion; IMP:FlyBase.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 2: Evidence at transcript level;
KW Muscle protein; Reference proteome.
FT CHAIN 1..184
FT /note="Muscle-specific protein 20"
FT /id="PRO_0000204779"
FT DOMAIN 17..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 157..181
FT /note="Calponin-like"
FT CONFLICT 13
FT /note="S -> G (in Ref. 1; CAA68746)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20190 MW; B291ACA92AED3873 CRC64;
MSLERAVRAK IASKRNPEMD KEAQEWIEAI IAEKFPAGQS YEDVLKDGQV LCKLINVLSP
NAVPKVNSSG GQFKFMENIN NFQKALKEYG VPDIDVFQTV DLYEKKDIAN VTNTIFALGR
ATYKHADFKG PFLGPKPADE CKRDFTEEQL KAGQTIVGLQ AGSNKGATQA GQNLGAGRKI
LLGK
