ID   MP44_MYXVL              Reviewed;         590 AA.
AC   Q9Q8Q1;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Probable metalloendopeptidase G1-type;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=m045L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
CC   -!- FUNCTION: Seems to be involved in viral proteins maturation by cleavage
CC       at Ala-Gly-|-Xaa motifs. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the peptidase M44 family. {ECO:0000305}.
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DR   EMBL; AF170726; AAF14933.1; -; Genomic_DNA.
DR   RefSeq; NP_051759.1; NC_001132.2.
DR   SMR; Q9Q8Q1; -.
DR   MEROPS; M44.001; -.
DR   GeneID; 932107; -.
DR   KEGG; vg:932107; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR005072; Peptidase_M44.
DR   Pfam; PF03410; Peptidase_M44; 1.
DR   PIRSF; PIRSF015679; Peptidase_M44; 1.
DR   SUPFAM; SSF63411; SSF63411; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..590
FT                   /note="Probable metalloendopeptidase G1-type"
FT                   /id="PRO_0000218450"
FT   ACT_SITE        44
FT                   /evidence="ECO:0000255"
FT   BINDING         41
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   590 AA;  68225 MW;  1DEE178930C75884 CRC64;
     MIVFDNGTRV FINSSTNKDI YVGFSGFGFE KDIGGILGIA HLLEHILISF DASRFVANAS
     TARSYMSFWC TPIRGRATSV DAVRTLISWF FDKDGLKDDF PVSKIKYHIK ELENEYYFRN
     EVFHCMDALT FLANGDLYNG GRLSMLDRLE DIPLILRDRM RTIIGPNVVI FVRELNDVVL
     SLLANTFGRL PACPLTIPCT VRTIIGGKTI MMPSPFYTVM VRVEPSLHNI LSILCLYEIY
     HLVDYETVDN KLYVTFSFIH EHDYERFLQG SGRLNLTIYK KIRLCYGDDF LMNVYLSFPC
     IRHDIFDYLT IVNTDTSSMI SSLERDIYQS VRTGDYIVVY PNFSNTMSNT ADRQLHKTVV
     INPNIVYASQ PTTSIDLMKK QTHNEMYIKY SDAGFIDYVQ LALGLRRKIH KHVHGIHIRH
     QFSADDIKTI LESDTFMKYS KSKPAAMYQY LILSFFVSGN TIEDILQHRE SVVKLCRTYK
     NKIVLGKQTR YDIQTLSSFV CGIFKGPSVT SEYLTDIMWK LKRKGLIYSL EFVELQKNMF
     YLFMFTIYPE DVTTYLSSRK LFTSRCVVVS KKGNTEDFSS MKKDIIIKLR