ID   MP44_RFVKA              Reviewed;         590 AA.
AC   Q9Q926;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Probable metalloendopeptidase G1-type;
DE            EC=3.4.24.-;
GN   Name=GP045L; Synonyms=S045L;
OS   Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS   Kasza)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=10272;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA   Willer D.O., McFadden G., Evans D.H.;
RT   "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL   Virology 264:319-343(1999).
CC   -!- FUNCTION: Seems to be involved in viral proteins maturation by cleavage
CC       at Ala-Gly-|-Xaa motifs. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the peptidase M44 family. {ECO:0000305}.
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DR   EMBL; AF170722; AAF17927.1; -; Genomic_DNA.
DR   RefSeq; NP_051934.1; NC_001266.1.
DR   SMR; Q9Q926; -.
DR   MEROPS; M44.001; -.
DR   PRIDE; Q9Q926; -.
DR   GeneID; 1486888; -.
DR   KEGG; vg:1486888; -.
DR   Proteomes; UP000000868; Genome.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR005072; Peptidase_M44.
DR   Pfam; PF03410; Peptidase_M44; 1.
DR   PIRSF; PIRSF015679; Peptidase_M44; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..590
FT                   /note="Probable metalloendopeptidase G1-type"
FT                   /id="PRO_0000218451"
FT   ACT_SITE        44
FT                   /evidence="ECO:0000255"
FT   BINDING         41
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   590 AA;  68428 MW;  B72B1584533B7513 CRC64;
     MIVFDNGVRV FINTSTNKDI YVGISGFGFE KDIGGILGTA HLLEHILISF DVSRFIANAS
     TARSYMSFWC TSIRGRSTPV DAIRTLISWF FDRDGLKHYF PVSKIKYHIK ELENEYYFRN
     EVFHCMDALT FLANGDLYNG GRLSMLDRLD DMPLILQDRM CAITGPNIVI FVRELNDVVL
     SLLVSTFGTL PSCPLTIPCT LPTPIGGKII MMPSPFYTVM VRVQPSLYNI LSILCLYEIY
     HLVDYETVNN KLYVTISFIH EHEYESFLHG SARLNFTIYK KIRLHYGDDF LMNMYLSFPC
     IRHDIFDYLT IINTNVSTMI PSLEQNIYQS IKTGDYIVVY PNFSNTMSNV ADRQLHKTVV
     IDTNIVYVTK PTTVIDLMKK HTHNDMYIKY SDTEFIDYVQ LALGLRRKIH KNVNGIHIRH
     QFSADDIKTI LESETFMKYS KSKPAAMYQY LILSFFVSGN TIEDILQHRE SVIKLCRTYK
     NKILLGKQTR YDIQTLSSFV CGIFKGPSIT SEYLTDIMWK LKRKGLIYSL EFVELQKNMF
     YLFMFTIYPE DVTSYLTSRK LFTSRCVVVS KKCNVEDFSS MKKDIIIKLR