ID   MP44_YLDV               Reviewed;         590 AA.
AC   Q9DHR2;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Probable metalloendopeptidase G1-type;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=50L;
OS   Yaba-like disease virus (YLDV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=132475;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=314293; Simiiformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11277691; DOI=10.1006/viro.2000.0761;
RA   Lee H.-J., Essani K., Smith G.L.;
RT   "The genome sequence of Yaba-like disease virus, a yatapoxvirus.";
RL   Virology 281:170-192(2001).
CC   -!- FUNCTION: Seems to be involved in viral proteins maturation by cleavage
CC       at Ala-Gly-|-Xaa motifs. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the peptidase M44 family. {ECO:0000305}.
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DR   EMBL; AJ293568; CAC21288.1; -; Genomic_DNA.
DR   RefSeq; NP_073435.1; NC_002642.1.
DR   SMR; Q9DHR2; -.
DR   MEROPS; M44.001; -.
DR   GeneID; 918685; -.
DR   KEGG; vg:918685; -.
DR   Proteomes; UP000136581; Genome.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR005072; Peptidase_M44.
DR   Pfam; PF03410; Peptidase_M44; 1.
DR   PIRSF; PIRSF015679; Peptidase_M44; 1.
DR   SUPFAM; SSF63411; SSF63411; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..590
FT                   /note="Probable metalloendopeptidase G1-type"
FT                   /id="PRO_0000218452"
FT   ACT_SITE        44
FT                   /evidence="ECO:0000255"
FT   BINDING         41
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   590 AA;  68626 MW;  7D7D0DB8A596233B CRC64;
     MIVLSNGVRI FINSNMNKDI YLGIASFGFE NDIGEILGIA HLLEHILISF DSSKFVANAS
     TARKYMSFWC CSIKGKSNYI DSINTLISWF FNNNKLRDNF CLNDIKNHIK ELENEYYFRN
     EVFHCMDVLT FLENGDLYNG GRIDMLNNLE SVNNMLYNRM HKIIGPNIVI FVKELNKNCL
     MLIQNSFGTL PSCPMSFSFP NFSNIDGKII MMPSPFYTVM IKVSLSISNV ISIMCLFETY
     HLIDYETVGN DLYVTLSFVK ESDYENFING VSTLKFNNVP NYTVLSLCDD FLMNAYLCFP
     WLSNDINNYL STVRYSQNMF KNLEEDIQNS ILLKKYIVVY PHFSKTVFNK NDSQMHKIVI
     LDCLNEIKED QLPKLNVNLM KKQTKNEIFI KYNDSSLIKY IIFAIGYKNN ILRGNEGVSI
     HHQFSSEDIK SILESDTFLK YSKSKPAAMY QYLLLSFFVS GYSIEDILLN RESTIKLLKQ
     YNNKILFGKK SRYDITTKSN FVCGIIKNKN INNNVITNTM WELKKKGLIY SMEHTKIDKR
     IFYIFMFTIY PDEVFLYLSK KFLSHCLIVS KTGNIEDFSS MKKDVIIKLC