ID   MP63_MYCBO              Reviewed;         159 AA.
AC   P0A5Q3; A0A1R3Y1V1; O08224; P97175; X2BJC5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Immunogenic protein MPB63;
DE   AltName: Full=16 kDa immunoprotective extracellular protein;
DE   AltName: Full=Antigen MPB63;
DE   Flags: Precursor;
GN   Name=mpb63; OrderedLocusNames=BQ2027_MB1961C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Tokyo;
RA   Kamiie K., Matsuda S., Kobayashi A., Kobayashi K.;
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AB048799; BAB39210.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIU00564.1; -; Genomic_DNA.
DR   RefSeq; NP_855611.1; NC_002945.3.
DR   RefSeq; WP_003409684.1; NC_002945.4.
DR   AlphaFoldDB; P0A5Q3; -.
DR   SMR; P0A5Q3; -.
DR   EnsemblBacteria; SIU00564; SIU00564; BQ2027_MB1961C.
DR   PATRIC; fig|233413.5.peg.2152; -.
DR   OMA; VTMNNGM; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   Gene3D; 2.60.40.1240; -; 1.
DR   InterPro; IPR029050; Immunoprotect_excell_Ig-like.
DR   InterPro; IPR015250; MPT63-like.
DR   Pfam; PF09167; DUF1942; 1.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   CHAIN           30..159
FT                   /note="Immunogenic protein MPB63"
FT                   /id="PRO_0000021735"
SQ   SEQUENCE   159 AA;  16514 MW;  EB563E1EAABCE428 CRC64;
     MKLTTMIKTA VAVVAMAAIA TFAAPVALAA YPITGKLGSE LTMTDTVGQV VLGWKVSDLK
     SSTAVIPGYP VAGQVWEATA TVNAIRGSVT PAVSQFNART ADGINYRVLW QAAGPDTISG
     ATIPQGEQST GKIYFDVTGP SPTIVAMNNG MEDLLIWEP