MP70_MYCTU
ID MP70_MYCTU Reviewed; 193 AA.
AC P9WNF5; L0TDT6; P0A668; Q48934; Q48946; Q48947; Q48948; Q50656; Q50769;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Immunogenic protein MPT70;
DE Flags: Precursor;
GN Name=mpt70; OrderedLocusNames=Rv2875; ORFNames=MTCY274.06;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=7871388; DOI=10.1111/j.1365-3083.1995.tb03565.x;
RA Matsumoto S., Matsuo T., Ohara N., Hotokezaka H., Naitoh M., Minami J.,
RA Yamada T.;
RT "Cloning and sequencing of a unique antigen MPT70 from Mycobacterium
RT tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle
RT vector.";
RL Scand. J. Immunol. 41:281-287(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBUNIT: Generally found as a monomer; homodimer in culture fluids.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; D37968; BAA07184.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP45677.1; -; Genomic_DNA.
DR PIR; F70923; F70923.
DR RefSeq; NP_217391.1; NC_000962.3.
DR RefSeq; WP_003414644.1; NZ_NVQJ01000006.1.
DR PDB; 1NYO; NMR; -; A=31-193.
DR PDBsum; 1NYO; -.
DR AlphaFoldDB; P9WNF5; -.
DR SMR; P9WNF5; -.
DR STRING; 83332.Rv2875; -.
DR PaxDb; P9WNF5; -.
DR DNASU; 887724; -.
DR GeneID; 45426864; -.
DR GeneID; 887724; -.
DR KEGG; mtu:Rv2875; -.
DR TubercuList; Rv2875; -.
DR eggNOG; COG2335; Bacteria.
DR OMA; RINNANV; -.
DR PhylomeDB; P9WNF5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 2.30.180.10; -; 1.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR Pfam; PF02469; Fasciclin; 1.
DR SMART; SM00554; FAS1; 1.
DR SUPFAM; SSF82153; SSF82153; 1.
DR PROSITE; PS50213; FAS1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000250"
FT CHAIN 31..193
FT /note="Immunogenic protein MPT70"
FT /id="PRO_0000008786"
FT DOMAIN 57..189
FT /note="FAS1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 37..44
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 54..57
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 60..64
FT /evidence="ECO:0007829|PDB:1NYO"
FT TURN 68..70
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 71..78
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 88..91
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 93..98
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 103..108
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 111..117
FT /evidence="ECO:0007829|PDB:1NYO"
FT HELIX 123..130
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 132..135
FT /evidence="ECO:0007829|PDB:1NYO"
FT TURN 139..141
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 144..147
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 151..158
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 163..165
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 178..183
FT /evidence="ECO:0007829|PDB:1NYO"
FT STRAND 185..187
FT /evidence="ECO:0007829|PDB:1NYO"
SQ SEQUENCE 193 AA; 19073 MW; 228695731C3FFB00 CRC64;
MKVKNTIAAT SFAAAGLAAL AVAVSPPAAA GDLVGPGCAE YAAANPTGPA SVQGMSQDPV
AVAASNNPEL TTLTAALSGQ LNPQVNLVDT LNSGQYTVFA PTNAAFSKLP ASTIDELKTN
SSLLTSILTY HVVAGQTSPA NVVGTRQTLQ GASVTVTGQG NSLKVGNADV VCGGVSTANA
TVYMIDSVLM PPA
