ID   MPA5B_PHLPR             Reviewed;         284 AA.
AC   Q40963;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Pollen allergen Phl p 5b;
DE   AltName: Full=Allergen Phl p Vb;
DE   AltName: Allergen=Phl p 5b;
DE   Flags: Precursor; Fragment;
OS   Phleum pratense (Common timothy).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type); Poinae;
OC   Phleum.
OX   NCBI_TaxID=15957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Agrostideae; TISSUE=Pollen;
RX   PubMed=7729555; DOI=10.1016/0014-5793(95)00259-c;
RA   Bufe A., Schramm G., Keown M.B., Schlaak M., Becker W.M.;
RT   "Major allergen Phl p Vb in timothy grass is a novel pollen RNase.";
RL   FEBS Lett. 363:6-12(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   Bufe A.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 150-251, SUBUNIT, AND DISULFIDE
RP   BOND.
RX   PubMed=12077438; DOI=10.1107/s0907444902007254;
RA   Rajashankar K., Bufe A., Weber W., Eschenburg S., Lindner B., Betzel C.;
RT   "Structure of the functional domain of the major grass-pollen allergen Phlp
RT   5b.";
RL   Acta Crystallogr. D 58:1175-1181(2002).
CC   -!- FUNCTION: Has ribonuclease activity. May be involved in host-pathogen
CC       interactions.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:12077438}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Causes grass pollen
CC       allergy.
CC   -!- SIMILARITY: Belongs to the Poa p IX/Phl p VI allergen family.
CC       {ECO:0000305}.
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DR   EMBL; Z27083; CAA81609.1; -; mRNA.
DR   PDB; 1L3P; X-ray; 1.98 A; A=150-251.
DR   PDBsum; 1L3P; -.
DR   AlphaFoldDB; Q40963; -.
DR   SMR; Q40963; -.
DR   Allergome; 558; Phl p 5.
DR   Allergome; 567; Phl p 5.0201.
DR   EvolutionaryTrace; Q40963; -.
DR   GO; GO:0004540; F:ribonuclease activity; IDA:CACAO.
DR   Gene3D; 1.20.120.320; -; 2.
DR   InterPro; IPR002914; Poa_pIX/Phl_pVI.
DR   InterPro; IPR035506; Pollen_allergen/Os.
DR   Pfam; PF01620; Pollen_allerg_2; 2.
DR   SUPFAM; SSF81736; SSF81736; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Disulfide bond; Signal.
FT   SIGNAL          <1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..284
FT                   /note="Pollen allergen Phl p 5b"
FT                   /id="PRO_0000021746"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        205
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:12077438"
FT   NON_TER         1
FT   HELIX           152..155
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           158..173
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           177..179
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           180..195
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   TURN            196..198
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           203..205
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           207..218
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   TURN            219..222
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           225..227
FT                   /evidence="ECO:0007829|PDB:1L3P"
FT   HELIX           228..250
FT                   /evidence="ECO:0007829|PDB:1L3P"
SQ   SEQUENCE   284 AA;  28002 MW;  E949FB3E0985295E CRC64;
     AAAAVPRRGP RGGPGRSYTA DAGYAPATPA AAGAAAGKAT TEEQKLIEDI NVGFKAAVAA
     AASVPAADKF KTFEAAFTSS SKAAAAKAPG LVPKLDAAYS VAYKAAVGAT PEAKFDSFVA
     SLTEALRVIA GALEVHAVKP VTEEPGMAKI PAGELQIIDK IDAAFKVAAT AAATAPADDK
     FTVFEAAFNK AIKESTGGAY DTYKCIPSLE AAVKQAYAAT VAAAPQVKYA VFEAALTKAI
     TAMSEVQKVS QPATGAATVA AGAATTAAGA ASGAATVAAG GYKV