ID   MPAC1_CARBE             Reviewed;         160 AA.
AC   P38949;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Major pollen allergen Car b 1 isoforms 1A and 1B;
DE   AltName: Full=Allergen Car b I;
DE   AltName: Allergen=Car b 1;
OS   Carpinus betulus (European hornbeam) (Carpinus caucasica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Betulaceae; Carpinus.
OX   NCBI_TaxID=12990;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RX   PubMed=1603091; DOI=10.1016/0161-5890(92)90180-6;
RA   Nedergaard Larsen J., Stroeman P., Ipsen H.;
RT   "PCR based cloning and sequencing of isogenes encoding the tree pollen
RT   major allergen Car b I from Carpinus betulus, hornbeam.";
RL   Mol. Immunol. 29:703-711(1992).
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- MISCELLANEOUS: The sequence shown is that of isoform 1A.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; X66932; CAA47366.1; -; mRNA.
DR   EMBL; X66918; CAA47357.1; -; mRNA.
DR   AlphaFoldDB; P38949; -.
DR   SMR; P38949; -.
DR   Allergome; 180; Car b 1.
DR   Allergome; 181; Car b 1.0101.
DR   Allergome; 182; Car b 1.0102.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   SMART; SM01037; Bet_v_1; 1.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Pathogenesis-related protein; Plant defense.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..160
FT                   /note="Major pollen allergen Car b 1 isoforms 1A and 1B"
FT                   /id="PRO_0000154185"
FT   VARIANT         38
FT                   /note="V -> A (in isoform 1B)"
FT   VARIANT         63
FT                   /note="I -> S (in isoform 1B)"
FT   VARIANT         133
FT                   /note="K -> E (in isoform 1B)"
SQ   SEQUENCE   160 AA;  17402 MW;  DE891173C8E587AE CRC64;
     MGVFNYEAET PSVIPAARLF KSYVLDGDKL IPKVAPQVIS SVENVGGNGG PGTIKNITFA
     EGIPFKFVKE RVDEVDNANF KYNYTVIEGD VLGDKLEKVS HELKIVAAPG GGSIVKISSK
     FHAKGYHEVN AEKMKGAKEM AEKLLRAVES YLLAHTAEYN