MPAC1_CORAV
ID MPAC1_CORAV Reviewed; 160 AA.
AC Q08407;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Major pollen allergen Cor a 1 isoforms 5, 6, 11 and 16;
DE AltName: Full=Allergen Cor a I;
DE AltName: Allergen=Cor a 1;
OS Corylus avellana (European hazel) (Corylus maxima).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Betulaceae; Corylus.
OX NCBI_TaxID=13451;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pollen;
RX PubMed=7916686; DOI=10.1111/j.1432-1033.1993.tb17669.x;
RA Breiteneder H., Ferreira F., Hoffmann-Sommergruber K., Ebner C.,
RA Breitenbach M., Rumpold H., Kraft D., Scheiner O.;
RT "Four recombinant isoforms of Cor a I, the major allergen of hazel pollen,
RT show different IgE-binding properties.";
RL Eur. J. Biochem. 212:355-362(1993).
CC -!- ALLERGEN: Causes an allergic reaction in human. The Cor a 1 isoforms
CC display different antigenic and allergenic properties.
CC -!- MISCELLANEOUS: The sequence shown is that of clone Cor a I/5.
CC -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR EMBL; X70999; CAA50327.1; -; mRNA.
DR EMBL; X71000; CAA50328.1; -; mRNA.
DR EMBL; X70997; CAA50325.1; -; mRNA.
DR EMBL; X70998; CAA50326.1; -; mRNA.
DR PIR; S30053; S30053.
DR PIR; S30054; S30054.
DR PIR; S30055; S30055.
DR PIR; S30056; S30056.
DR AlphaFoldDB; Q08407; -.
DR SMR; Q08407; -.
DR Allergome; 232; Cor a 1.
DR Allergome; 233; Cor a 1.0101.
DR Allergome; 234; Cor a 1.0102.
DR Allergome; 235; Cor a 1.0103.
DR Allergome; 236; Cor a 1.0104.
DR ABCD; Q08407; 1 sequenced antibody.
DR GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000916; Bet_v_I/MLP.
DR InterPro; IPR024949; Bet_v_I_allergen.
DR InterPro; IPR023393; START-like_dom_sf.
DR Pfam; PF00407; Bet_v_1; 1.
DR PRINTS; PR00634; BETALLERGEN.
DR SMART; SM01037; Bet_v_1; 1.
DR PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE 1: Evidence at protein level;
KW Allergen; Pathogenesis-related protein; Plant defense.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..160
FT /note="Major pollen allergen Cor a 1 isoforms 5, 6, 11 and
FT 16"
FT /id="PRO_0000154187"
FT VARIANT 8
FT /note="V -> A (in clone COR A 1/11)"
FT VARIANT 11
FT /note="P -> T (in clone COR A 1/11)"
FT VARIANT 15
FT /note="P -> S (in clone COR A 1/16)"
FT VARIANT 46
FT /note="E -> G (in clone COR A 1/16)"
FT VARIANT 81
FT /note="T -> K (in clone COR A 1/6 and 1/16)"
FT VARIANT 101
FT /note="H -> S (in clone COR A 1/6 and 1/16)"
FT VARIANT 114
FT /note="I -> T (in clone COR A 1/16)"
FT VARIANT 134
FT /note="M -> I (in clone COR A 1/11)"
SQ SEQUENCE 160 AA; 17512 MW; 1FA022ABE8884E48 CRC64;
MGVFNYEVET PSVIPAARLF KSYVLDGDKL IPKVAPQAIT SVENVEGNGG PGTIKNITFG
EGSRYKYVKE RVDEVDNTNF TYSYTVIEGD VLGDKLEKVC HELKIVAAPG GGSILKISSK
FHAKGDHEIN AEEMKGAKEM AEKLLRAVET YLLAHSAEYN
