ID   MPAH1_HOLLA             Reviewed;         265 AA.
AC   P43216; Q39975;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Major pollen allergen Hol l 1;
DE   AltName: Full=Allergen Hol l 1.0101/1.0102;
DE   AltName: Full=Allergen Hol l I;
DE   AltName: Allergen=Hol l 1;
DE   Flags: Precursor;
OS   Holcus lanatus (Yorkshire-fog) (Nothoholcus lanatus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type); Holcinae;
OC   Holcus.
OX   NCBI_TaxID=29679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Aveneae; TISSUE=Pollen;
RA   Schramm G.D., Bufe A., Becker W.M., Schlaak M.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-265.
RC   STRAIN=cv. Aveneae; TISSUE=Pollen;
RX   PubMed=9215246; DOI=10.1016/s0091-6749(97)80012-7;
RA   Schramm G.D., Bufe A., Petersen A., Haas H., Schlaak M., Becker W.M.;
RT   "Mapping of IgE-binding epitopes on the recombinant major group I allergen
RT   of velvet grass pollen, rHol l 1.";
RL   J. Allergy Clin. Immunol. 99:781-787(1997).
RN   [3]
RP   CHARACTERIZATION.
RC   STRAIN=cv. Aveneae; TISSUE=Pollen;
RX   PubMed=8768803; DOI=10.1159/000237328;
RA   Schramm G.D., Petersen A., Bufe A., Schlaak M., Becker W.M.;
RT   "Identification and characterization of the major allergens of velvet grass
RT   (Holcus lanatus), Hol l 1 and Hol l 5.";
RL   Int. Arch. Allergy Immunol. 110:354-363(1996).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Causes grass pollen
CC       allergy. Binds to IgE.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin B subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z27084; CAA81610.1; -; mRNA.
DR   EMBL; Z68893; CAA93121.1; -; mRNA.
DR   PIR; S38581; S38581.
DR   AlphaFoldDB; P43216; -.
DR   SMR; P43216; -.
DR   Allergome; 405; Hol l 1.
DR   Allergome; 406; Hol l 1.0101.
DR   Allergome; 407; Hol l 1.0102.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0019953; P:sexual reproduction; IEA:InterPro.
DR   Gene3D; 2.40.40.10; -; 1.
DR   Gene3D; 2.60.40.760; -; 1.
DR   InterPro; IPR007118; Expan_Lol_pI.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR007117; Expansin_CBD.
DR   InterPro; IPR036749; Expansin_CBD_sf.
DR   InterPro; IPR005795; LolPI.
DR   InterPro; IPR009009; RlpA-like_DPBB.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   Pfam; PF03330; DPBB_1; 1.
DR   Pfam; PF01357; Expansin_C; 1.
DR   PRINTS; PR01225; EXPANSNFAMLY.
DR   PRINTS; PR00829; LOLP1ALLERGN.
DR   SMART; SM00837; DPBB_1; 1.
DR   SUPFAM; SSF49590; SSF49590; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50843; EXPANSIN_CBD; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   1: Evidence at protein level;
KW   Allergen; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..265
FT                   /note="Major pollen allergen Hol l 1"
FT                   /id="PRO_0000008719"
FT   DOMAIN          63..169
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DOMAIN          183..264
FT                   /note="Expansin-like CBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00078"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         103
FT                   /note="T -> S (in Hol l 1.0102)"
SQ   SEQUENCE   265 AA;  28590 MW;  1FE23B3EE198AD6D CRC64;
     MASSSRSVLL LVAALFAVFL GSAHGIAKVP PGPNITATYG DEWLDAKSTW YGKPTGAGPK
     DNGGACGYKD VDKPPFSGMT GCGNTPIFKD GRGCGSCFEI KCTKPESCSG EPVTVHITDD
     NEEPIAPYHF DLSGHAFGSM AKKGEEQKLR SAGELELKFR RVKCKYPDGT KPTFHVEKGS
     NPNYLALLVK YIDGDGDVVA VDIKEKGKDK WIELKESWGA VWRVDTPDKL TGPFTVRYTT
     EGGTKGEAED VIPEGWKADT AYEAK