MPAP1_PHAAQ
ID MPAP1_PHAAQ Reviewed; 269 AA.
AC Q41260;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Major pollen allergen Pha a 1;
DE AltName: Full=Allergen Pha a I;
DE AltName: Allergen=Pha a 1;
DE Flags: Precursor;
OS Phalaris aquatica (Canary grass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Poodae; Poeae; Poeae Chloroplast Group 1 (Aveneae type);
OC Phalaridinae; Phalaris.
OX NCBI_TaxID=28479;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pollen;
RX PubMed=8564724; DOI=10.1111/j.1365-2222.1995.tb00028.x;
RA Suphioglu C., Singh M.B.;
RT "Cloning, sequencing and expression in Escherichia coli of Pha a 1 and four
RT isoforms of Pha a 5, the major allergens of canary grass pollen.";
RL Clin. Exp. Allergy 25:853-865(1995).
RN [2]
RP PROTEIN SEQUENCE OF 30-49, AND ALLERGEN.
RX PubMed=7687099; DOI=10.1111/j.1398-9995.1993.tb00728.x;
RA Suphioglu C., Singh M.B., Simpson R.J., Ward L.D., Knox R.B.;
RT "Identification of canary grass (Phalaris aquatica) pollen allergens by
RT immunoblotting: IgE and IgG antibody-binding studies.";
RL Allergy 48:273-281(1993).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Causes grass pollen
CC allergy. Binds to IgE. {ECO:0000269|PubMed:7687099}.
CC -!- SIMILARITY: Belongs to the expansin family. Expansin B subfamily.
CC {ECO:0000305}.
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DR EMBL; S80654; AAB35984.1; -; mRNA.
DR AlphaFoldDB; Q41260; -.
DR SMR; Q41260; -.
DR Allergome; 3486; Pha a 1.0101.
DR Allergome; 547; Pha a 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0019953; P:sexual reproduction; IEA:InterPro.
DR Gene3D; 2.40.40.10; -; 1.
DR Gene3D; 2.60.40.760; -; 1.
DR InterPro; IPR007118; Expan_Lol_pI.
DR InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR InterPro; IPR007117; Expansin_CBD.
DR InterPro; IPR036749; Expansin_CBD_sf.
DR InterPro; IPR005795; LolPI.
DR InterPro; IPR009009; RlpA-like_DPBB.
DR InterPro; IPR036908; RlpA-like_sf.
DR Pfam; PF03330; DPBB_1; 1.
DR Pfam; PF01357; Expansin_C; 1.
DR PRINTS; PR01225; EXPANSNFAMLY.
DR PRINTS; PR00829; LOLP1ALLERGN.
DR SMART; SM00837; DPBB_1; 1.
DR SUPFAM; SSF49590; SSF49590; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR PROSITE; PS50843; EXPANSIN_CBD; 1.
DR PROSITE; PS50842; EXPANSIN_EG45; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:7687099"
FT CHAIN 30..269
FT /note="Major pollen allergen Pha a 1"
FT /id="PRO_0000008718"
FT DOMAIN 67..173
FT /note="Expansin-like EG45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DOMAIN 187..268
FT /note="Expansin-like CBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00078"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 37
FT /note="P -> G (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 29011 MW; 05883A458ACE877F CRC64;
MMKMVCSSSS SSLLVVAALL AVFVGSAQGI AKVPPGPNIT AEYGDKWLDA KSTWYGKPTG
AGPKDNGGAC GYKDVDKAPF NGMTGCGNTP IFKDGRGCGS CFELKCSKPE SCSGEPITVH
ITDDNEEPIA PYHFDLSGHA FGSMAKKGEE ENVRGAGELE LQFRRVKCKY PDGTKPTFHV
EKGSNPNYLA LLVKYVDGDG DVVAVDIKEK GKDKWIELKE SWGAIWRIDT PDKLTGPFTV
RYTTEGGTKA EFEDVIPEGW KADTHDASK