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MPAP1_PHAAQ
ID   MPAP1_PHAAQ             Reviewed;         269 AA.
AC   Q41260;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Major pollen allergen Pha a 1;
DE   AltName: Full=Allergen Pha a I;
DE   AltName: Allergen=Pha a 1;
DE   Flags: Precursor;
OS   Phalaris aquatica (Canary grass).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Poodae; Poeae; Poeae Chloroplast Group 1 (Aveneae type);
OC   Phalaridinae; Phalaris.
OX   NCBI_TaxID=28479;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RX   PubMed=8564724; DOI=10.1111/j.1365-2222.1995.tb00028.x;
RA   Suphioglu C., Singh M.B.;
RT   "Cloning, sequencing and expression in Escherichia coli of Pha a 1 and four
RT   isoforms of Pha a 5, the major allergens of canary grass pollen.";
RL   Clin. Exp. Allergy 25:853-865(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-49, AND ALLERGEN.
RX   PubMed=7687099; DOI=10.1111/j.1398-9995.1993.tb00728.x;
RA   Suphioglu C., Singh M.B., Simpson R.J., Ward L.D., Knox R.B.;
RT   "Identification of canary grass (Phalaris aquatica) pollen allergens by
RT   immunoblotting: IgE and IgG antibody-binding studies.";
RL   Allergy 48:273-281(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Causes grass pollen
CC       allergy. Binds to IgE. {ECO:0000269|PubMed:7687099}.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin B subfamily.
CC       {ECO:0000305}.
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DR   EMBL; S80654; AAB35984.1; -; mRNA.
DR   AlphaFoldDB; Q41260; -.
DR   SMR; Q41260; -.
DR   Allergome; 3486; Pha a 1.0101.
DR   Allergome; 547; Pha a 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0019953; P:sexual reproduction; IEA:InterPro.
DR   Gene3D; 2.40.40.10; -; 1.
DR   Gene3D; 2.60.40.760; -; 1.
DR   InterPro; IPR007118; Expan_Lol_pI.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR007117; Expansin_CBD.
DR   InterPro; IPR036749; Expansin_CBD_sf.
DR   InterPro; IPR005795; LolPI.
DR   InterPro; IPR009009; RlpA-like_DPBB.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   Pfam; PF03330; DPBB_1; 1.
DR   Pfam; PF01357; Expansin_C; 1.
DR   PRINTS; PR01225; EXPANSNFAMLY.
DR   PRINTS; PR00829; LOLP1ALLERGN.
DR   SMART; SM00837; DPBB_1; 1.
DR   SUPFAM; SSF49590; SSF49590; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50843; EXPANSIN_CBD; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000269|PubMed:7687099"
FT   CHAIN           30..269
FT                   /note="Major pollen allergen Pha a 1"
FT                   /id="PRO_0000008718"
FT   DOMAIN          67..173
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DOMAIN          187..268
FT                   /note="Expansin-like CBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00078"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        37
FT                   /note="P -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  29011 MW;  05883A458ACE877F CRC64;
     MMKMVCSSSS SSLLVVAALL AVFVGSAQGI AKVPPGPNIT AEYGDKWLDA KSTWYGKPTG
     AGPKDNGGAC GYKDVDKAPF NGMTGCGNTP IFKDGRGCGS CFELKCSKPE SCSGEPITVH
     ITDDNEEPIA PYHFDLSGHA FGSMAKKGEE ENVRGAGELE LQFRRVKCKY PDGTKPTFHV
     EKGSNPNYLA LLVKYVDGDG DVVAVDIKEK GKDKWIELKE SWGAIWRIDT PDKLTGPFTV
     RYTTEGGTKA EFEDVIPEGW KADTHDASK
 
 
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