ID   MPAP5_PHLPR             Reviewed;         312 AA.
AC   Q40960;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pollen allergen Phl p 5.0101 {ECO:0000305};
DE   AltName: Full=Allergen Phl p 5a {ECO:0000305};
DE   AltName: Full=Allergen Phl p V {ECO:0000305};
DE   AltName: Allergen=Phl p 5.0101 {ECO:0000305};
DE   Flags: Precursor;
OS   Phleum pratense (Common timothy).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type); Poinae;
OC   Phleum.
OX   NCBI_TaxID=15957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALLERGEN.
RX   PubMed=7691956;
RA   Vrtala S., Sperr W.R., Reimitzer I., van Ree R., Laffer S., Mueller W.D.,
RA   Valent P., Lechner K., Rumpold H., Kraft D., Scheiner O., Valenta R.;
RT   "cDNA cloning of a major allergen from timothy grass (Phleum pratense)
RT   pollen; characterization of the recombinant Phl pV allergen.";
RL   J. Immunol. 151:4773-4781(1993).
RN   [2]
RP   STRUCTURE BY NMR OF 55-285, AND ALLERGEN.
RX   PubMed=28532654; DOI=10.1016/j.jaci.2017.05.005;
RA   Gobl C., Focke-Tejkl M., Najafi N., Schrank E., Madl T., Kosol S.,
RA   Madritsch C., Dorofeeva Y., Flicker S., Thalhamer J., Valenta R.,
RA   Zangger K., Tjandra N.;
RT   "Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic
RT   activity.";
RL   J. Allergy Clin. Immunol. 140:1187-1191(2017).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Causes grass pollen
CC       allergy. Binds to IgE of patients who are allergic to P.pratense.
CC       {ECO:0000269|PubMed:28532654, ECO:0000269|PubMed:7691956}.
CC   -!- SIMILARITY: Belongs to the Poa p IX/Phl p VI allergen family.
CC       {ECO:0000305}.
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DR   EMBL; X74735; CAA52753.1; -; Genomic_DNA.
DR   PIR; S37400; S37400.
DR   PDB; 2M64; NMR; -; A=55-285.
DR   PDBsum; 2M64; -.
DR   AlphaFoldDB; Q40960; -.
DR   SMR; Q40960; -.
DR   Allergome; 558; Phl p 5.
DR   Allergome; 559; Phl p 5.0101.
DR   ABCD; Q40960; 24 sequenced antibodies.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.120.320; -; 2.
DR   InterPro; IPR002914; Poa_pIX/Phl_pVI.
DR   InterPro; IPR035506; Pollen_allergen/Os.
DR   Pfam; PF01620; Pollen_allerg_2; 1.
DR   SUPFAM; SSF81736; SSF81736; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..312
FT                   /note="Pollen allergen Phl p 5.0101"
FT                   /id="PRO_5004231642"
FT   HELIX           62..66
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   TURN            67..69
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           70..81
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   STRAND          82..84
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   STRAND          86..88
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           89..107
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           120..142
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           148..166
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           190..205
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   STRAND          207..211
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           212..227
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   TURN            228..230
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           241..251
FT                   /evidence="ECO:0007829|PDB:2M64"
FT   HELIX           260..280
FT                   /evidence="ECO:0007829|PDB:2M64"
SQ   SEQUENCE   312 AA;  31102 MW;  BC94B13818CEE07F CRC64;
     MAVHQYTVAL FLAVALVAGP AASYAADLGY GPATPAAPAA GYTPATPAAP AEAAPAGKAT
     TEEQKLIEKI NAGFKAALAA AAGVQPADKY RTFVATFGAA SNKAFAEGLS GEPKGAAESS
     SKAALTSKLD AAYKLAYKTA EGATPEAKYD AYVATLSEAL RIIAGTLEVH AVKPAAEEVK
     VIPAGELQVI EKVDAAFKVA ATAANAAPAN DKFTVFEAAF NDAIKASTGG AYESYKFIPA
     LEAAVKQAYA ATVATAPEVK YTVFETALKK AITAMSEAQK AAKPAAAATA TATAAVGAAT
     GAATAATGGY KV