MPAT5_AMBTR
ID MPAT5_AMBTR Reviewed; 73 AA.
AC P10414;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Pollen allergen Amb t 5;
DE AltName: Full=Allergen Amb t V;
DE AltName: Full=Allergen Ra5G;
DE AltName: Allergen=Amb t 5;
DE Flags: Precursor;
OS Ambrosia trifida (Giant ragweed).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Ambrosia.
OX NCBI_TaxID=4214;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pollen;
RX PubMed=1711499; DOI=10.1016/0378-1119(91)90416-9;
RA Ghosh B., Perry M.P., Marsh D.G.;
RT "Cloning the cDNA encoding the AmbtV allergen from giant ragweed (Ambrosia
RT trifida) pollen.";
RL Gene 101:231-238(1991).
RN [2]
RP PROTEIN SEQUENCE OF 34-73.
RC TISSUE=Pollen;
RX PubMed=3862954; DOI=10.1016/0161-5890(85)90076-8;
RA Goodfriend L., Choudhury A.M., Klapper D.G., Coulter K.M., Dorval G.,
RA del Carpio J., Osterland C.K.;
RT "Ra5G, a homologue of Ra5 in giant ragweed pollen: isolation, HLA-DR-
RT associated activity and amino acid sequence.";
RL Mol. Immunol. 22:899-906(1985).
RN [3]
RP STRUCTURE BY NMR OF 34-73.
RC TISSUE=Pollen;
RX PubMed=1606135; DOI=10.1021/bi00137a005;
RA Metzler W.J., Valentine K., Roebber M., Friedrichs M.S., Marsh D.G.,
RA Mueller L.;
RT "Determination of the three-dimensional solution structure of ragweed
RT allergen Amb t V by nuclear magnetic resonance spectroscopy.";
RL Biochemistry 31:5117-5127(1992).
RN [4]
RP STRUCTURE BY NMR OF 34-73.
RC TISSUE=Pollen;
RA Warren G.L., Turner C.J., Petsko G.A., Brunger A.T.;
RL Submitted (APR-1998) to the PDB data bank.
CC -!- SUBUNIT: Monomer.
CC -!- ALLERGEN: Causes an allergic reaction in human.
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DR EMBL; X56279; CAA39726.1; -; mRNA.
DR EMBL; M38782; AAB02877.1; -; mRNA.
DR PIR; JQ1001; ARRA5G.
DR PDB; 1BBG; NMR; -; A=34-73.
DR PDB; 2BBG; NMR; -; A=34-73.
DR PDB; 3BBG; NMR; -; A=34-73.
DR PDBsum; 1BBG; -.
DR PDBsum; 2BBG; -.
DR PDBsum; 3BBG; -.
DR AlphaFoldDB; P10414; -.
DR BMRB; P10414; -.
DR SMR; P10414; -.
DR Allergome; 3074; Amb t 5.0101.
DR Allergome; 32; Amb t 5.
DR EvolutionaryTrace; P10414; -.
DR Gene3D; 3.30.160.80; -; 1.
DR InterPro; IPR005611; Amb_V_allergen.
DR InterPro; IPR036712; Amb_V_allergen_sf.
DR Pfam; PF03913; Ragweed_pollen; 1.
DR PIRSF; PIRSF002697; Amb_V_allergen; 1.
DR SMART; SM00816; Amb_V_allergen; 1.
DR SUPFAM; SSF57296; SSF57296; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Allergen; Direct protein sequencing; Disulfide bond; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..33
FT /evidence="ECO:0000255"
FT /id="PRO_0000021751"
FT CHAIN 34..73
FT /note="Pollen allergen Amb t 5"
FT /id="PRO_0000021752"
FT DISULFID 38..68
FT /evidence="ECO:0000269|PubMed:1606135"
FT DISULFID 44..59
FT /evidence="ECO:0000269|PubMed:1606135"
FT DISULFID 51..61
FT /evidence="ECO:0000269|PubMed:1606135"
FT DISULFID 52..72
FT /evidence="ECO:0000269|PubMed:1606135"
FT STRAND 39..42
FT /evidence="ECO:0007829|PDB:1BBG"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:1BBG"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:1BBG"
FT STRAND 60..64
FT /evidence="ECO:0007829|PDB:1BBG"
FT HELIX 65..72
FT /evidence="ECO:0007829|PDB:1BBG"
SQ SEQUENCE 73 AA; 8058 MW; 23B412AF6A8BA143 CRC64;
MKNIFMLTLF ILIITSTIKA IGSTNEVDEI KQEDDGLCYE GTNCGKVGKY CCSPIGKYCV
CYDSKAICNK NCT
