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MPC1_ARATH
ID   MPC1_ARATH              Reviewed;         110 AA.
AC   Q949R9;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Mitochondrial pyruvate carrier 1 {ECO:0000305};
DE            Short=AtMPC1 {ECO:0000305};
GN   Name=MPC1 {ECO:0000305};
GN   OrderedLocusNames=At5g20090 {ECO:0000312|Araport:AT5G20090};
GN   ORFNames=F28I16.240 {ECO:0000312|EMBL:AF296836};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAK93615.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION.
RX   PubMed=24842572; DOI=10.1093/mp/ssu061;
RA   Li C.L., Wang M., Ma X.Y., Zhang W.;
RT   "NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation
RT   of guard cell ion channels and drought stress responses in Arabidopsis.";
RL   Mol. Plant 7:1508-1521(2014).
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000269|PubMed:24842572}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P53157}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q949R9-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; AF296836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92792.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92793.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM68303.1; -; Genomic_DNA.
DR   EMBL; AY050938; AAK93615.1; -; mRNA.
DR   EMBL; AY079418; AAL85149.1; -; mRNA.
DR   EMBL; AY085758; AAM62976.1; -; mRNA.
DR   RefSeq; NP_001078606.1; NM_001085137.1. [Q949R9-1]
DR   RefSeq; NP_001330067.1; NM_001343637.1. [Q949R9-1]
DR   RefSeq; NP_197509.1; NM_122016.3. [Q949R9-1]
DR   AlphaFoldDB; Q949R9; -.
DR   SMR; Q949R9; -.
DR   STRING; 3702.AT5G20090.1; -.
DR   TCDB; 2.A.105.1.4; the mitochondrial pyruvate carrier (mpc) family.
DR   PaxDb; Q949R9; -.
DR   PRIDE; Q949R9; -.
DR   ProteomicsDB; 250883; -. [Q949R9-1]
DR   DNASU; 832131; -.
DR   EnsemblPlants; AT5G20090.1; AT5G20090.1; AT5G20090. [Q949R9-1]
DR   EnsemblPlants; AT5G20090.2; AT5G20090.2; AT5G20090. [Q949R9-1]
DR   EnsemblPlants; AT5G20090.4; AT5G20090.4; AT5G20090. [Q949R9-1]
DR   GeneID; 832131; -.
DR   Gramene; AT5G20090.1; AT5G20090.1; AT5G20090. [Q949R9-1]
DR   Gramene; AT5G20090.2; AT5G20090.2; AT5G20090. [Q949R9-1]
DR   Gramene; AT5G20090.4; AT5G20090.4; AT5G20090. [Q949R9-1]
DR   KEGG; ath:AT5G20090; -.
DR   Araport; AT5G20090; -.
DR   TAIR; locus:2147695; AT5G20090.
DR   eggNOG; KOG1590; Eukaryota.
DR   InParanoid; Q949R9; -.
DR   OMA; FLQHFWG; -.
DR   PhylomeDB; Q949R9; -.
DR   PRO; PR:Q949R9; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q949R9; baseline and differential.
DR   Genevisible; Q949R9; AT.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IMP:UniProtKB.
DR   GO; GO:0010119; P:regulation of stomatal movement; IMP:TAIR.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..110
FT                   /note="Mitochondrial pyruvate carrier 1"
FT                   /id="PRO_0000431615"
FT   TRANSMEM        20..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..61
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  12438 MW;  2FC4D3DB5674FC5E CRC64;
     MATSRFQAFL NSPIGPKTTH FWGPIANWGF VAAGLVDMQK PPEMISGNMS SAMCVYSALF
     MRFAWMVQPR NYLLLACHAS NETVQLYQLS RWARAQGYLS SKKEEEKPSQ
 
 
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