ID   MPC1_BOVIN              Reviewed;         109 AA.
AC   Q3ZCG2;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Mitochondrial pyruvate carrier 1;
DE   AltName: Full=Brain protein 44-like protein;
GN   Name=MPC1; Synonyms=BRP44L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP   ALA-2, AND MASS SPECTROMETRY.
RX   PubMed=17060615; DOI=10.1073/pnas.0607719103;
RA   Carroll J., Fearnley I.M., Walker J.E.;
RT   "Definition of the mitochondrial proteome by measurement of molecular
RT   masses of membrane proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:16170-16175(2006).
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:Q9Y5U8}.
CC   -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC       of MPC1 and MPC2. {ECO:0000250|UniProtKB:P63030}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U8}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:17060615}.
CC   -!- MASS SPECTROMETRY: Mass=12299.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17060615};
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; BC102377; AAI02378.1; -; mRNA.
DR   RefSeq; NP_001070510.1; NM_001077042.2.
DR   AlphaFoldDB; Q3ZCG2; -.
DR   STRING; 9913.ENSBTAP00000039979; -.
DR   iPTMnet; Q3ZCG2; -.
DR   PaxDb; Q3ZCG2; -.
DR   PRIDE; Q3ZCG2; -.
DR   Ensembl; ENSBTAT00000040201; ENSBTAP00000039979; ENSBTAG00000027879.
DR   GeneID; 767977; -.
DR   KEGG; bta:767977; -.
DR   CTD; 51660; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027879; -.
DR   VGNC; VGNC:31569; MPC1.
DR   eggNOG; KOG1590; Eukaryota.
DR   GeneTree; ENSGT00510000046988; -.
DR   HOGENOM; CLU_099502_3_2_1; -.
DR   InParanoid; Q3ZCG2; -.
DR   OMA; CTTHFWG; -.
DR   OrthoDB; 1584711at2759; -.
DR   TreeFam; TF314444; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000027879; Expressed in omental fat pad and 110 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:17060615"
FT   CHAIN           2..109
FT                   /note="Mitochondrial pyruvate carrier 1"
FT                   /id="PRO_0000350552"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:17060615"
FT   MOD_RES         72
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P63030"
SQ   SEQUENCE   109 AA;  12389 MW;  E32C79DF8AA68124 CRC64;
     MAGALVRKAA DYVRSKDFRD YLMSTHFWGP VANWGLPIAA INDMKKSPEI ISGRMTFALC
     CYSLTFMRFA YKVQPRNWLL FACHATNEVA QLIQGGRLIR HEMSKKASA