ID   MPC1_CAEEL              Reviewed;         137 AA.
AC   Q21828;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable mitochondrial pyruvate carrier 1;
DE            Short=MPC1;
GN   Name=mpc-1 {ECO:0000312|WormBase:R07E5.13};
GN   ORFNames=R07E5.13 {ECO:0000312|WormBase:R07E5.13};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May mediate the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:Q9Y5U8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U8}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; BX284603; CAA83622.2; -; Genomic_DNA.
DR   PIR; S43605; S43605.
DR   RefSeq; NP_497894.2; NM_065493.2.
DR   AlphaFoldDB; Q21828; -.
DR   BioGRID; 56677; 24.
DR   STRING; 6239.R07E5.13; -.
DR   EPD; Q21828; -.
DR   PaxDb; Q21828; -.
DR   PeptideAtlas; Q21828; -.
DR   EnsemblMetazoa; R07E5.13.1; R07E5.13.1; WBGene00011119.
DR   GeneID; 259500; -.
DR   KEGG; cel:CELE_R07E5.13; -.
DR   UCSC; R07E5.13; c. elegans.
DR   CTD; 259500; -.
DR   WormBase; R07E5.13; CE47062; WBGene00011119; mpc-1.
DR   eggNOG; KOG1590; Eukaryota.
DR   GeneTree; ENSGT00940000171651; -.
DR   HOGENOM; CLU_099502_3_0_1; -.
DR   InParanoid; Q21828; -.
DR   OMA; AFKDMNA; -.
DR   OrthoDB; 1584711at2759; -.
DR   PhylomeDB; Q21828; -.
DR   PRO; PR:Q21828; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00011119; Expressed in larva and 3 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..137
FT                   /note="Probable mitochondrial pyruvate carrier 1"
FT                   /id="PRO_0000212804"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   137 AA;  15832 MW;  F8C98F9526A3F9DB CRC64;
     MSRVISKVTT YFKQHSTAEW KHYFLSTHFW GPVANWGLPL AALGDLKKNP DMISGPMTSA
     LLIYSSVFMR FAWHVQPRNL LLFACHFANF SAQGAQLGRF VNHNYLHYVE DPVHHKLMMK
     KEVLEHEHDA EVISKAH