ID   MPC1_DICDI              Reviewed;          97 AA.
AC   Q55GU4;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable mitochondrial pyruvate carrier 1;
DE            Short=MPC1;
GN   ORFNames=DDB_G0267508;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May mediate the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:Q9Y5U8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U8}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73207.2; -; Genomic_DNA.
DR   RefSeq; XP_647090.2; XM_641998.2.
DR   AlphaFoldDB; Q55GU4; -.
DR   STRING; 44689.DDB0266856; -.
DR   PaxDb; Q55GU4; -.
DR   EnsemblProtists; EAL73207; EAL73207; DDB_G0267508.
DR   GeneID; 8615894; -.
DR   KEGG; ddi:DDB_G0267508; -.
DR   dictyBase; DDB_G0267508; -.
DR   eggNOG; KOG1590; Eukaryota.
DR   HOGENOM; CLU_099502_5_1_1; -.
DR   InParanoid; Q55GU4; -.
DR   OMA; FLQHFWG; -.
DR   PhylomeDB; Q55GU4; -.
DR   PRO; PR:Q55GU4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..97
FT                   /note="Probable mitochondrial pyruvate carrier 1"
FT                   /id="PRO_0000350550"
FT   TRANSMEM        9..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11072 MW;  B46E32785C7D448E CRC64;
     MAERWTKMVG FLGAAANWTI PIASFMNLKN DPEKVDPIMT TTLAVYSAVF MRWAIAIYPP
     NYWLLGCHVA NEVAQLTQLG RYGKWKVFDS KQESDKQ