MPC1_DROME
ID MPC1_DROME Reviewed; 107 AA.
AC Q7KSC4;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Mitochondrial pyruvate carrier 1;
DE Short=MPC1;
GN Name=Mpc1; ORFNames=CG14290;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=22628558; DOI=10.1126/science.1218099;
RA Bricker D.K., Taylor E.B., Schell J.C., Orsak T., Boutron A., Chen Y.C.,
RA Cox J.E., Cardon C.M., Van Vranken J.G., Dephoure N., Redin C., Boudina S.,
RA Gygi S.P., Brivet M., Thummel C.S., Rutter J.;
RT "A mitochondrial pyruvate carrier required for pyruvate uptake in yeast,
RT Drosophila, and humans.";
RL Science 337:96-100(2012).
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000269|PubMed:22628558}.
CC -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC of MPC1 and MPC2. {ECO:0000250|UniProtKB:P63030}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:22628558}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22628558}.
CC -!- DISRUPTION PHENOTYPE: Viable on standard food, but sensitive to a
CC carbohydrate-only diet, with rapid lethality after transfer to a
CC sucrose medium. {ECO:0000269|PubMed:22628558}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55610.1; -; Genomic_DNA.
DR EMBL; AY095174; AAM12267.1; -; mRNA.
DR RefSeq; NP_001262720.1; NM_001275791.1.
DR RefSeq; NP_650762.1; NM_142505.2.
DR AlphaFoldDB; Q7KSC4; -.
DR SMR; Q7KSC4; -.
DR BioGRID; 67272; 2.
DR STRING; 7227.FBpp0083137; -.
DR TCDB; 2.A.105.1.3; the mitochondrial pyruvate carrier (mpc) family.
DR PaxDb; Q7KSC4; -.
DR PRIDE; Q7KSC4; -.
DR DNASU; 42268; -.
DR EnsemblMetazoa; FBtr0083723; FBpp0083137; FBgn0038662.
DR EnsemblMetazoa; FBtr0334525; FBpp0306592; FBgn0038662.
DR GeneID; 42268; -.
DR KEGG; dme:Dmel_CG14290; -.
DR UCSC; CG14290-RB; d. melanogaster.
DR CTD; 51660; -.
DR FlyBase; FBgn0038662; Mpc1.
DR VEuPathDB; VectorBase:FBgn0038662; -.
DR eggNOG; KOG1590; Eukaryota.
DR GeneTree; ENSGT00510000046988; -.
DR HOGENOM; CLU_099502_3_2_1; -.
DR InParanoid; Q7KSC4; -.
DR OMA; CTTHFWG; -.
DR OrthoDB; 1584711at2759; -.
DR PhylomeDB; Q7KSC4; -.
DR BioGRID-ORCS; 42268; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42268; -.
DR PRO; PR:Q7KSC4; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038662; Expressed in adult Malpighian tubule (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q7KSC4; baseline and differential.
DR Genevisible; Q7KSC4; DM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; ISS:FlyBase.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISS:FlyBase.
DR GO; GO:0006090; P:pyruvate metabolic process; IMP:FlyBase.
DR InterPro; IPR005336; MPC.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..107
FT /note="Mitochondrial pyruvate carrier 1"
FT /id="PRO_0000418369"
FT TRANSMEM 18..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..68
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 107 AA; 12261 MW; 7EB25755EBF6E445 CRC64;
MSIRRAMSTT ASKEWRDYFM STHFWGPVAN WGIPVAALAD TQKSPKFISG KMTLALTLYS
CIFMRFAYKV QPRNWLLFAC HATNATAQSI QGLRFLHYNY GSKEQQA
