MPC1_RAT
ID MPC1_RAT Reviewed; 109 AA.
AC P63031; Q4V8N5; Q9D6C0; Q9JLG5;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Mitochondrial pyruvate carrier 1;
DE AltName: Full=Apoptosis-regulating basic protein;
DE AltName: Full=Brain protein 44-like protein;
GN Name=Mpc1; Synonyms=Arbp, Brp44l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neuron;
RA Dong B., Hong M., Dongbing L., Jijie G., Bingren H.;
RT "A protein involved in apoptosis of rat neuronal cell.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000250|UniProtKB:Q9Y5U8}.
CC -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC of MPC1 and MPC2. {ECO:0000250|UniProtKB:P63030}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9Y5U8}; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000305}.
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DR EMBL; AF304429; AAG24885.1; -; mRNA.
DR EMBL; BC097287; AAH97287.1; -; mRNA.
DR RefSeq; NP_598245.1; NM_133561.1.
DR AlphaFoldDB; P63031; -.
DR SMR; P63031; -.
DR STRING; 10116.ENSRNOP00000017282; -.
DR GuidetoPHARMACOLOGY; 3022; -.
DR iPTMnet; P63031; -.
DR PhosphoSitePlus; P63031; -.
DR jPOST; P63031; -.
DR PaxDb; P63031; -.
DR PRIDE; P63031; -.
DR GeneID; 171087; -.
DR KEGG; rno:171087; -.
DR CTD; 51660; -.
DR RGD; 620902; Mpc1.
DR VEuPathDB; HostDB:ENSRNOG00000012415; -.
DR eggNOG; KOG1590; Eukaryota.
DR HOGENOM; CLU_099502_3_2_1; -.
DR InParanoid; P63031; -.
DR OMA; CTTHFWG; -.
DR OrthoDB; 1584711at2759; -.
DR PhylomeDB; P63031; -.
DR PRO; PR:P63031; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000012415; Expressed in heart and 20 other tissues.
DR Genevisible; P63031; RN.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
DR GO; GO:0061732; P:mitochondrial acetyl-CoA biosynthetic process from pyruvate; ISO:RGD.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISO:RGD.
DR InterPro; IPR005336; MPC.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q3ZCG2"
FT CHAIN 2..109
FT /note="Mitochondrial pyruvate carrier 1"
FT /id="PRO_0000212799"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q3ZCG2"
FT MOD_RES 72
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63030"
SQ SEQUENCE 109 AA; 12455 MW; E0536878BAA68124 CRC64;
MAGALVRKAA DYVRSKDFRD YLMSTHFWGP VANWGLPIAA INDMKKSPEI ISGRMTFALC
CYSLTFMRFA YKVQPRNWLL FACHVTNEVA QLIQGGRLIN YEMSKRPSA
