MPC1_SCHPO
ID MPC1_SCHPO Reviewed; 141 AA.
AC O74847;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 3.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Probable mitochondrial pyruvate carrier 1 {ECO:0000250|UniProtKB:P53157};
DE Short=MPC1 {ECO:0000250|UniProtKB:P53157};
GN Name=mpc1 {ECO:0000250|UniProtKB:P53157, ECO:0000312|PomBase:SPCC1235.11};
GN ORFNames=SPCC1235.11 {ECO:0000312|PomBase:SPCC1235.11};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA21115.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000250|UniProtKB:P53157}.
CC -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC of mpc1 and mpc2. {ECO:0000250|UniProtKB:P53157}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC Mitochondrion inner membrane {ECO:0000250|UniProtKB:P53157}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21115.2; -; Genomic_DNA.
DR PIR; T40885; T40885.
DR RefSeq; NP_587737.1; NM_001022732.2.
DR AlphaFoldDB; O74847; -.
DR BioGRID; 275740; 58.
DR STRING; 4896.SPCC1235.11.1; -.
DR MaxQB; O74847; -.
DR PaxDb; O74847; -.
DR EnsemblFungi; SPCC1235.11.1; SPCC1235.11.1:pep; SPCC1235.11.
DR GeneID; 2539169; -.
DR KEGG; spo:SPCC1235.11; -.
DR PomBase; SPCC1235.11; mpc1.
DR VEuPathDB; FungiDB:SPCC1235.11; -.
DR eggNOG; KOG1590; Eukaryota.
DR HOGENOM; CLU_099502_3_0_1; -.
DR InParanoid; O74847; -.
DR OMA; CTTHFWG; -.
DR PhylomeDB; O74847; -.
DR PRO; PR:O74847; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISO:PomBase.
DR InterPro; IPR005336; MPC.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..141
FT /note="Probable mitochondrial pyruvate carrier 1"
FT /id="PRO_0000318135"
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 141 AA; 16056 MW; 28CCFE93316E21E1 CRC64;
MNASEKLSQK AAQSVTRRFI TWLKSPDFRK YLCSTHFWGP LSNFGIPIAA ILDLKKDPRL
ISGRMTGALI LYSSVFMRYA WMVSPRNYLL LGCHAFNTTV QTAQGIRFVN FWYGKEGASK
QSVFENIMQA AKHPESGTRQ K
