ID   MPC2_CAEEL              Reviewed;         133 AA.
AC   O01578;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Probable mitochondrial pyruvate carrier 2;
DE            Short=MPC2;
GN   Name=mpc-2 {ECO:0000312|WormBase:F53F10.3};
GN   ORFNames=F53F10.3 {ECO:0000312|WormBase:F53F10.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May mediate the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:P38857}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P38857}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; FO080750; CCD66421.1; -; Genomic_DNA.
DR   PIR; T25797; T25797.
DR   RefSeq; NP_491234.1; NM_058833.5.
DR   AlphaFoldDB; O01578; -.
DR   SMR; O01578; -.
DR   BioGRID; 37431; 18.
DR   STRING; 6239.F53F10.3.2; -.
DR   EPD; O01578; -.
DR   PaxDb; O01578; -.
DR   PeptideAtlas; O01578; -.
DR   EnsemblMetazoa; F53F10.3.1; F53F10.3.1; WBGene00018765.
DR   GeneID; 171957; -.
DR   KEGG; cel:CELE_F53F10.3; -.
DR   UCSC; F53F10.3; c. elegans.
DR   CTD; 171957; -.
DR   WormBase; F53F10.3; CE28447; WBGene00018765; mpc-2.
DR   eggNOG; KOG1589; Eukaryota.
DR   GeneTree; ENSGT00510000047120; -.
DR   HOGENOM; CLU_099502_4_1_1; -.
DR   InParanoid; O01578; -.
DR   OMA; KPAWNHA; -.
DR   OrthoDB; 1422466at2759; -.
DR   PhylomeDB; O01578; -.
DR   PRO; PR:O01578; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00018765; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..133
FT                   /note="Probable mitochondrial pyruvate carrier 2"
FT                   /id="PRO_0000212803"
FT   TRANSMEM        40..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15074 MW;  BCF5E72C1A6A6E03 CRC64;
     MGPHRLLYQA LCKAGDKFVY PVLPAFAKPA WNHAAGPKTV FFWAPTIKWT LIGAGLADLA
     RPADKLSLYQ NSALFATGAI WTRYCLVITP INYYLSSVNF FVMCTGLAQL CRIAHYRYQN
     PDWETKEIME THN