MPC2_DICDI
ID MPC2_DICDI Reviewed; 133 AA.
AC Q55GU3;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Probable mitochondrial pyruvate carrier 2;
DE Short=MPC2;
GN ORFNames=DDB_G0268478;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May mediate the uptake of pyruvate into mitochondria.
CC {ECO:0000250|UniProtKB:P38857}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P38857}; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73692.1; -; Genomic_DNA.
DR RefSeq; XP_647091.1; XM_641999.1.
DR AlphaFoldDB; Q55GU3; -.
DR PaxDb; Q55GU3; -.
DR EnsemblProtists; EAL73692; EAL73692; DDB_G0268478.
DR GeneID; 8615895; -.
DR KEGG; ddi:DDB_G0268478; -.
DR dictyBase; DDB_G0268478; -.
DR eggNOG; ENOG502S29Z; Eukaryota.
DR HOGENOM; CLU_1900480_0_0_1; -.
DR InParanoid; Q55GU3; -.
DR OMA; WTYYATL; -.
DR PhylomeDB; Q55GU3; -.
DR PRO; PR:Q55GU3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005336; MPC.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..133
FT /note="Probable mitochondrial pyruvate carrier 2"
FT /id="PRO_0000350551"
FT TRANSMEM 39..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 133 AA; 14936 MW; B0B8C81421190004 CRC64;
MNALRGLLNK YTGNQIVFSN KYATTFFEKF PKLAFLNNVT NLAPMMKWSL SIVPITQILS
GTKLPENIDV YQASSLCATG SIWTYYATLI SPQNTGTRML AACNAAMAAC HGYNIYRRTK
WEKSQIIPIE NKN
