ID   MPC2_PONAB              Reviewed;         127 AA.
AC   Q5R4Z3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Mitochondrial pyruvate carrier 2;
DE   AltName: Full=Brain protein 44;
GN   Name=MPC2; Synonyms=BRP44;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:Q9D023}.
CC   -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC       of MPC1 and MPC2. {ECO:0000250|UniProtKB:Q9D023}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9D023}; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR861094; CAH93173.1; -; mRNA.
DR   RefSeq; NP_001126868.1; NM_001133396.1.
DR   AlphaFoldDB; Q5R4Z3; -.
DR   SMR; Q5R4Z3; -.
DR   STRING; 9601.ENSPPYP00000000639; -.
DR   GeneID; 100173880; -.
DR   KEGG; pon:100173880; -.
DR   CTD; 25874; -.
DR   eggNOG; KOG1589; Eukaryota.
DR   InParanoid; Q5R4Z3; -.
DR   OrthoDB; 1422466at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IEA:InterPro.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..127
FT                   /note="Mitochondrial pyruvate carrier 2"
FT                   /id="PRO_0000212795"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   127 AA;  14249 MW;  DE9E5EC9AB2ABF39 CRC64;
     MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKR GLVCAGLADM
     ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN FFVGAAGASQ LFRIWRYNQE
     LKAKAHK