ID   MPC2_RAT                Reviewed;         127 AA.
AC   P38718;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Mitochondrial pyruvate carrier 2;
DE   AltName: Full=Brain protein 44;
DE   AltName: Full=Protein 0-44;
GN   Name=Mpc2; Synonyms=Brp44;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=3022128; DOI=10.1128/mcb.6.3.768-778.1986;
RA   Tsou A.-P., Lai C., Danielson P., Noonan D.J., Sutcliffe J.G.;
RT   "Structural characterization of a heterogeneous family of rat brain
RT   mRNAs.";
RL   Mol. Cell. Biol. 6:768-778(1986).
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:P38857}.
CC   -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC       of MPC1 and MPC2. {ECO:0000250|UniProtKB:P38857}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P38857}; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P38718-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P38718-2; Sequence=VSP_006719;
CC   -!- TISSUE SPECIFICITY: Liver, kidney, and brain.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; M13095; AAA40791.1; -; Genomic_DNA.
DR   EMBL; M13094; AAA40791.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001071111.1; NM_001077643.2. [P38718-1]
DR   RefSeq; XP_006250188.1; XM_006250126.2. [P38718-2]
DR   AlphaFoldDB; P38718; -.
DR   SMR; P38718; -.
DR   BioGRID; 1199117; 1.
DR   STRING; 10116.ENSRNOP00000004206; -.
DR   GuidetoPHARMACOLOGY; 3023; -.
DR   iPTMnet; P38718; -.
DR   PhosphoSitePlus; P38718; -.
DR   jPOST; P38718; -.
DR   PaxDb; P38718; -.
DR   PRIDE; P38718; -.
DR   Ensembl; ENSRNOT00000004206; ENSRNOP00000004206; ENSRNOG00000003150. [P38718-1]
DR   GeneID; 100359982; -.
DR   KEGG; rno:100359982; -.
DR   CTD; 25874; -.
DR   RGD; 1563422; Mpc2.
DR   eggNOG; KOG1589; Eukaryota.
DR   GeneTree; ENSGT00510000047120; -.
DR   HOGENOM; CLU_099502_4_1_1; -.
DR   InParanoid; P38718; -.
DR   OMA; KPAWNHA; -.
DR   OrthoDB; 1422466at2759; -.
DR   PhylomeDB; P38718; -.
DR   PRO; PR:P38718; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003150; Expressed in kidney and 20 other tissues.
DR   Genevisible; P38718; RN.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0061732; P:mitochondrial acetyl-CoA biosynthetic process from pyruvate; ISO:RGD.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISO:RGD.
DR   GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISO:RGD.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..127
FT                   /note="Mitochondrial pyruvate carrier 2"
FT                   /id="PRO_0000212796"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         26
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D023"
FT   VAR_SEQ         117..127
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_006719"
SQ   SEQUENCE   127 AA;  14258 MW;  BE8AEC82CA4405A6 CRC64;
     MAAAGARGLR ATYHRLMDKV ELLLPKKLRP LYNHPAGPRT VFFWAPIMKW GLVCAGLADM
     ARPAEKLSTA QSTVLMATGF IWSRYSLVII PKNWSLFAVN FFVGSAGASQ LFRIWKYNQE
     LKSKGIQ