ID   MPC2_SCHPO              Reviewed;         118 AA.
AC   Q09896;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Probable mitochondrial pyruvate carrier 2 {ECO:0000250|UniProtKB:P38857};
DE            Short=MPC2 {ECO:0000250|UniProtKB:P38857};
GN   Name=mpc2 {ECO:0000250|UniProtKB:P38857, ECO:0000312|PomBase:SPAC24B11.09};
GN   ORFNames=SPAC24B11.09 {ECO:0000312|PomBase:SPAC24B11.09};
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000250|UniProtKB:P38857}.
CC   -!- SUBUNIT: The functional 150 kDa pyruvate import complex is a heteromer
CC       of mpc1 and mpc2. {ECO:0000250|UniProtKB:P38857}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P38857}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA91774.1; -; Genomic_DNA.
DR   PIR; S62554; S62554.
DR   RefSeq; NP_592846.1; NM_001018247.2.
DR   AlphaFoldDB; Q09896; -.
DR   SMR; Q09896; -.
DR   BioGRID; 277977; 20.
DR   STRING; 4896.SPAC24B11.09.1; -.
DR   MaxQB; Q09896; -.
DR   PaxDb; Q09896; -.
DR   EnsemblFungi; SPAC24B11.09.1; SPAC24B11.09.1:pep; SPAC24B11.09.
DR   GeneID; 2541475; -.
DR   KEGG; spo:SPAC24B11.09; -.
DR   PomBase; SPAC24B11.09; mpc2.
DR   VEuPathDB; FungiDB:SPAC24B11.09; -.
DR   eggNOG; KOG1589; Eukaryota.
DR   HOGENOM; CLU_099502_1_0_1; -.
DR   InParanoid; Q09896; -.
DR   OMA; KPAWNHA; -.
DR   PhylomeDB; Q09896; -.
DR   PRO; PR:Q09896; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:PomBase.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISO:PomBase.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..118
FT                   /note="Probable mitochondrial pyruvate carrier 2"
FT                   /id="PRO_0000212802"
FT   TRANSMEM        19..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        50..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   118 AA;  13536 MW;  69FABB4E558E44B7 CRC64;
     MFRAGFKRFW NHPAGPKTVH FWAPAMKWTL VLSGIGDYAR SPEYLSIRQY AALCATGAIW
     TRWSLIVRPK NYFNATVNFF LAIVGAVQVS RILVYQRQQK RITAQSEQRT ELARSLAA