MPCP1_ARATH
ID MPCP1_ARATH Reviewed; 309 AA.
AC Q7DNC3;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Mitochondrial phosphate carrier protein 1, mitochondrial;
DE AltName: Full=Mitochondrial phosphate transporter 1;
DE Short=MPT1;
DE AltName: Full=Phosphate transporter 3;3;
GN Name=MPT1; Synonyms=AT2, PHT3;3; OrderedLocusNames=At2g17270;
GN ORFNames=F5J6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [6]
RP GENE FAMILY, TISSUE SPECIFICITY, INDUCTION BY SALT, AND FUNCTION.
RX PubMed=22937061; DOI=10.1371/journal.pone.0043530;
RA Zhu W., Miao Q., Sun D., Yang G., Wu C., Huang J., Zheng C.;
RT "The mitochondrial phosphate transporters modulate plant responses to salt
RT stress via affecting ATP and gibberellin metabolism in Arabidopsis
RT thaliana.";
RL PLoS ONE 7:E43530-E43530(2012).
CC -!- FUNCTION: Transport of phosphate groups from the cytosol to the
CC mitochondrial matrix. Mediates salt stress tolerance through an ATP-
CC dependent pathway and via modulation of the gibberellin metabolism.
CC {ECO:0000269|PubMed:22937061}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in stems, leaves and flowers. Strong
CC expression in the stamens of flowers. {ECO:0000269|PubMed:22937061}.
CC -!- INDUCTION: By salt stress. {ECO:0000269|PubMed:22937061}.
CC -!- MISCELLANEOUS: Plants overexpressing MPT1/PHT3;3 display increased
CC sensitivity to salt stress. {ECO:0000305|PubMed:22937061}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002685; AEC06606.1; -; Genomic_DNA.
DR EMBL; BT010199; AAQ22668.1; -; mRNA.
DR EMBL; AK227300; BAE99316.1; -; mRNA.
DR PIR; B84550; B84550.
DR RefSeq; NP_179319.1; NM_127282.3.
DR AlphaFoldDB; Q7DNC3; -.
DR SMR; Q7DNC3; -.
DR STRING; 3702.AT2G17270.1; -.
DR PaxDb; Q7DNC3; -.
DR PRIDE; Q7DNC3; -.
DR ProteomicsDB; 238269; -.
DR EnsemblPlants; AT2G17270.1; AT2G17270.1; AT2G17270.
DR GeneID; 816233; -.
DR Gramene; AT2G17270.1; AT2G17270.1; AT2G17270.
DR KEGG; ath:AT2G17270; -.
DR Araport; AT2G17270; -.
DR TAIR; locus:2827555; AT2G17270.
DR eggNOG; KOG0767; Eukaryota.
DR HOGENOM; CLU_039456_0_1_1; -.
DR InParanoid; Q7DNC3; -.
DR OMA; CSTMQQL; -.
DR OrthoDB; 963446at2759; -.
DR PhylomeDB; Q7DNC3; -.
DR PRO; PR:Q7DNC3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q7DNC3; baseline and differential.
DR Genevisible; Q7DNC3; AT.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990547; P:mitochondrial phosphate ion transmembrane transport; IEA:InterPro.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044677; Pic2/Mir1-like.
DR PANTHER; PTHR45671; PTHR45671; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Mitochondrial phosphate carrier protein 1,
FT mitochondrial"
FT /id="PRO_0000421695"
FT TOPO_DOM 1..15
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..74
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..111
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..167
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..208
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..268
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..309
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REPEAT 16..100
FT /note="Solcar 1"
FT REPEAT 109..193
FT /note="Solcar 2"
FT REPEAT 210..289
FT /note="Solcar 3"
SQ SEQUENCE 309 AA; 34278 MW; EF9B6CD736B6B565 CRC64;
MTRVKSKLDE ELSSPWFYTV CTMGGMLSAG TTHLAITPLD VLKVNMQVNP VKYNSIPSGF
STLLREHGHS YLWRGWSGKL LGYGVQGGCR FGLYEYFKTL YSDVLPNHNR TSIYFLSSAS
AQIFADMALC PFEAIKVRVQ TQPMFAKGLL DGFPRVYRSE GLAGFHRGLF PLWCRNLPFS
MVMFSTFEQS VEFIYQKIIQ KRKQDCSKAQ QLGVTCLAGY TAGAVGTIIS NPADVVLSSL
YNNKAKNVLQ AVRNIGFVGL FTRSLPVRIT IVGPVITLQW FFYDAIKVLS GFPTSGGVKK
PVDAAKLSV
