MPCP_CAEEL
ID MPCP_CAEEL Reviewed; 340 AA.
AC P40614;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Phosphate carrier protein, mitochondrial;
DE Short=PTP;
DE Flags: Precursor;
GN ORFNames=F01G4.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7803813; DOI=10.3109/10425179409020854;
RA Runswick M.J., Philippides A., Lauria G., Walker J.E.;
RT "Extension of the mitochondrial transporter super-family: sequences of five
RT members from the nematode worm, Caenorhabditis elegans.";
RL DNA Seq. 4:281-291(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Transport of phosphate groups from the cytosol to the
CC mitochondrial matrix. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; X76113; CAA53719.1; -; mRNA.
DR EMBL; Z68341; CAA92769.1; -; Genomic_DNA.
DR EMBL; Z73103; CAA92769.1; JOINED; Genomic_DNA.
DR PIR; T19105; T19105.
DR RefSeq; NP_001076672.1; NM_001083203.2.
DR AlphaFoldDB; P40614; -.
DR SMR; P40614; -.
DR BioGRID; 43119; 15.
DR DIP; DIP-25979N; -.
DR IntAct; P40614; 1.
DR MINT; P40614; -.
DR STRING; 6239.F01G4.6b.2; -.
DR EPD; P40614; -.
DR PaxDb; P40614; -.
DR PeptideAtlas; P40614; -.
DR EnsemblMetazoa; F01G4.6a.1; F01G4.6a.1; WBGene00008505.
DR GeneID; 178020; -.
DR KEGG; cel:CELE_F01G4.6; -.
DR UCSC; F01G4.6a.2; c. elegans.
DR CTD; 178020; -.
DR WormBase; F01G4.6a; CE09162; WBGene00008505; -.
DR eggNOG; KOG0767; Eukaryota.
DR GeneTree; ENSGT00970000196094; -.
DR HOGENOM; CLU_039456_0_1_1; -.
DR InParanoid; P40614; -.
DR PRO; PR:P40614; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00008505; Expressed in larva and 4 other tissues.
DR ExpressionAtlas; P40614; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990547; P:mitochondrial phosphate ion transmembrane transport; IEA:InterPro.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044677; Pic2/Mir1-like.
DR PANTHER; PTHR45671; PTHR45671; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 28..340
FT /note="Phosphate carrier protein, mitochondrial"
FT /id="PRO_0000019259"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 41..125
FT /note="Solcar 1"
FT REPEAT 138..222
FT /note="Solcar 2"
FT REPEAT 239..317
FT /note="Solcar 3"
SQ SEQUENCE 340 AA; 36674 MW; 93B093A101C1D0A7 CRC64;
MSVFSQLAES SKQNPFSLPV RSGNCASAVS APGQVEFGSG KYYAYCALGG VLSCGITHTA
IVPLDLVKCR IQVNPEKYTG IATGFRTTIA EEGARALVKG WAPTLLGYSA QGLGKFGFYE
IFKNVYADML GEENAYLYRT SLYLAASASA EFFADILLAP MEATKVRIQT SPGAPPTLRG
CAPMIYKAEG LTGFYKGLPP LWMRQIPYTM MKFACFEKTV EALYQYVVPK PRAECSKAEQ
LVVTFVAGYI AGVFCAIVSH PADTVVSKLN QDSQATAGGI LKKLGFAGVW KGLVPRIIMI
GTLTALQWFI YDSVKVALNL PRPPPPEMPA SLKAKLAAQQ
