MPF1_SCHPO
ID MPF1_SCHPO Reviewed; 581 AA.
AC Q10238; Q2L4W5;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Meiotic PUF family protein 1;
GN Name=mpf1; ORFNames=SPAC4G9.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RA Nojima H.;
RT "Mrb1, a meiosis-specific RNA binding protein, is essential for meiotic
RT progression and forms a nuclear foci that resembles the Mei2 dot.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: RNA-binding protein essential for meiotic progression.
CC {ECO:0000269|Ref.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB248102; BAE78594.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA93555.1; -; Genomic_DNA.
DR PIR; T38864; T38864.
DR RefSeq; NP_593687.1; NM_001019119.2.
DR AlphaFoldDB; Q10238; -.
DR SMR; Q10238; -.
DR BioGRID; 279566; 1.
DR STRING; 4896.SPAC4G9.05.1; -.
DR PaxDb; Q10238; -.
DR EnsemblFungi; SPAC4G9.05.1; SPAC4G9.05.1:pep; SPAC4G9.05.
DR PomBase; SPAC4G9.05; mpf1.
DR VEuPathDB; FungiDB:SPAC4G9.05; -.
DR eggNOG; KOG1488; Eukaryota.
DR HOGENOM; CLU_475795_0_0_1; -.
DR InParanoid; Q10238; -.
DR OMA; QTIFENC; -.
DR PhylomeDB; Q10238; -.
DR PRO; PR:Q10238; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISO:PomBase.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IBA:GO_Central.
DR CDD; cd07920; Pumilio; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR033712; Pumilio_RNA-bd.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR Pfam; PF00806; PUF; 7.
DR SMART; SM00025; Pumilio; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50302; PUM; 8.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Meiosis; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..581
FT /note="Meiotic PUF family protein 1"
FT /id="PRO_0000075936"
FT DOMAIN 225..580
FT /note="PUM-HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT REPEAT 291..326
FT /note="Pumilio 1"
FT REPEAT 327..362
FT /note="Pumilio 2"
FT REPEAT 363..398
FT /note="Pumilio 3"
FT REPEAT 403..438
FT /note="Pumilio 4"
FT REPEAT 439..474
FT /note="Pumilio 5"
FT REPEAT 475..510
FT /note="Pumilio 6"
FT REPEAT 518..554
FT /note="Pumilio 7"
FT REPEAT 555..581
FT /note="Pumilio 8"
SQ SEQUENCE 581 AA; 66866 MW; 93A360BA7BD0A40E CRC64;
MQRDEERPID FGMSLELPKT PNDVNYVKKL ITQILYLQTL VSEQQKKIES STLEVQKKKD
QIRELERIYE MNPKSFLTLR RTPALKLLPE TLSVELSNEV NLTSSTTSSC VKPSPYLTNC
NLKNKDTFPV SKNNCSLSSG IFTNSNGTNN CFSTHPKSLD DAKDNVVPKK LNDTDQFPLW
SKNETIDPID LGYSFISPFS MSFASKGNEI LDPGESTNKN LFYEFPNGTT EPFEKNSVHS
GKETLQYSAT ISKWKAMIEQ IIFQNDQAAS LSLQQQLKNE DIEDNINLIN TILPFSVTLM
KNKFGNFLIQ KCFEYSTEAQ LQSFSYFLKK HVKELSIDAF GSHVLQKSLE IYPERFTNNL
IEELIECLPA TLMQRHSCHV WQKFFETRRK SLVDGIFDHF NKKMQGKWLQ VSVSEMGSLV
VQTIFENCKE KDKRTCLDEI INNMDQIICG QWGNWVIQHI IEHGSEPDKQ RILNSLLKEV
ESYSTNRYAS KVVERALRVC HVTFFDRYVK EITTPQNELP TIFLQEIASN QYGNYIVQYL
LQVATPSQIN LMAEHLKKHM VSLRGHKYGQ RIAALVEKSK S