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MPF1_SCHPO
ID   MPF1_SCHPO              Reviewed;         581 AA.
AC   Q10238; Q2L4W5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Meiotic PUF family protein 1;
GN   Name=mpf1; ORFNames=SPAC4G9.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RA   Nojima H.;
RT   "Mrb1, a meiosis-specific RNA binding protein, is essential for meiotic
RT   progression and forms a nuclear foci that resembles the Mei2 dot.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: RNA-binding protein essential for meiotic progression.
CC       {ECO:0000269|Ref.1}.
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DR   EMBL; AB248102; BAE78594.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAA93555.1; -; Genomic_DNA.
DR   PIR; T38864; T38864.
DR   RefSeq; NP_593687.1; NM_001019119.2.
DR   AlphaFoldDB; Q10238; -.
DR   SMR; Q10238; -.
DR   BioGRID; 279566; 1.
DR   STRING; 4896.SPAC4G9.05.1; -.
DR   PaxDb; Q10238; -.
DR   EnsemblFungi; SPAC4G9.05.1; SPAC4G9.05.1:pep; SPAC4G9.05.
DR   PomBase; SPAC4G9.05; mpf1.
DR   VEuPathDB; FungiDB:SPAC4G9.05; -.
DR   eggNOG; KOG1488; Eukaryota.
DR   HOGENOM; CLU_475795_0_0_1; -.
DR   InParanoid; Q10238; -.
DR   OMA; QTIFENC; -.
DR   PhylomeDB; Q10238; -.
DR   PRO; PR:Q10238; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISO:PomBase.
DR   GO; GO:0010608; P:post-transcriptional regulation of gene expression; IBA:GO_Central.
DR   CDD; cd07920; Pumilio; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033133; PUM-HD.
DR   InterPro; IPR033712; Pumilio_RNA-bd.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   Pfam; PF00806; PUF; 7.
DR   SMART; SM00025; Pumilio; 7.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50302; PUM; 8.
DR   PROSITE; PS50303; PUM_HD; 1.
PE   4: Predicted;
KW   Meiosis; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..581
FT                   /note="Meiotic PUF family protein 1"
FT                   /id="PRO_0000075936"
FT   DOMAIN          225..580
FT                   /note="PUM-HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00318"
FT   REPEAT          291..326
FT                   /note="Pumilio 1"
FT   REPEAT          327..362
FT                   /note="Pumilio 2"
FT   REPEAT          363..398
FT                   /note="Pumilio 3"
FT   REPEAT          403..438
FT                   /note="Pumilio 4"
FT   REPEAT          439..474
FT                   /note="Pumilio 5"
FT   REPEAT          475..510
FT                   /note="Pumilio 6"
FT   REPEAT          518..554
FT                   /note="Pumilio 7"
FT   REPEAT          555..581
FT                   /note="Pumilio 8"
SQ   SEQUENCE   581 AA;  66866 MW;  93A360BA7BD0A40E CRC64;
     MQRDEERPID FGMSLELPKT PNDVNYVKKL ITQILYLQTL VSEQQKKIES STLEVQKKKD
     QIRELERIYE MNPKSFLTLR RTPALKLLPE TLSVELSNEV NLTSSTTSSC VKPSPYLTNC
     NLKNKDTFPV SKNNCSLSSG IFTNSNGTNN CFSTHPKSLD DAKDNVVPKK LNDTDQFPLW
     SKNETIDPID LGYSFISPFS MSFASKGNEI LDPGESTNKN LFYEFPNGTT EPFEKNSVHS
     GKETLQYSAT ISKWKAMIEQ IIFQNDQAAS LSLQQQLKNE DIEDNINLIN TILPFSVTLM
     KNKFGNFLIQ KCFEYSTEAQ LQSFSYFLKK HVKELSIDAF GSHVLQKSLE IYPERFTNNL
     IEELIECLPA TLMQRHSCHV WQKFFETRRK SLVDGIFDHF NKKMQGKWLQ VSVSEMGSLV
     VQTIFENCKE KDKRTCLDEI INNMDQIICG QWGNWVIQHI IEHGSEPDKQ RILNSLLKEV
     ESYSTNRYAS KVVERALRVC HVTFFDRYVK EITTPQNELP TIFLQEIASN QYGNYIVQYL
     LQVATPSQIN LMAEHLKKHM VSLRGHKYGQ RIAALVEKSK S
 
 
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