ID   MPG12_CANGA             Reviewed;         361 AA.
AC   Q6FRY2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase 2;
DE            EC=2.7.7.13;
DE   AltName: Full=ATP-mannose-1-phosphate guanylyltransferase 2;
DE   AltName: Full=GDP-mannose pyrophosphorylase 2;
GN   Name=MPG1; OrderedLocusNames=CAGL0H04983g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell wall synthesis where it is required for
CC       glycosylation. Involved in cell cycle progression through cell-size
CC       checkpoint (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; CR380954; CAG59945.1; -; Genomic_DNA.
DR   RefSeq; XP_447012.1; XM_447012.1.
DR   AlphaFoldDB; Q6FRY2; -.
DR   SMR; Q6FRY2; -.
DR   STRING; 5478.XP_447012.1; -.
DR   EnsemblFungi; CAG59945; CAG59945; CAGL0H04983g.
DR   GeneID; 2888449; -.
DR   KEGG; cgr:CAGL0H04983g; -.
DR   CGD; CAL0129988; PSA1.
DR   VEuPathDB; FungiDB:CAGL0H04983g; -.
DR   eggNOG; KOG1322; Eukaryota.
DR   HOGENOM; CLU_029499_0_0_1; -.
DR   InParanoid; Q6FRY2; -.
DR   OMA; HRDIGNP; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..361
FT                   /note="Mannose-1-phosphate guanyltransferase 2"
FT                   /id="PRO_0000248401"
SQ   SEQUENCE   361 AA;  39611 MW;  FCF021E334A6872B CRC64;
     MKGLILVGGY GTRLRPLTLS VPKPLVEFCN RPMILHQIEA LAEAGVTDIV LAVNYRPEVM
     VDTLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEKILKKD NSPFFVLNSD VICEYPFKEL
     AEFHKSHGGK GTIVATKVDE PSKYGVIVHD LGTPNLIDRF VEKPKEFVGN RINAGLYILN
     PEVIDLIEMK PTSIETETFP KLVNEKSLYT FDLEGFWMDV GQPKDFLAGT GLYLQSLSRR
     HPEKLSTGSN IVSNAIIDPT AKISPDAKIG PDVVIGPNCV IGSGVRIVRS VLLKNCVVKE
     NSLIKDTIVG WDSTIGRWCR LEGCAVLGHD VAVKDEVYVN GAKVLPHKSI SANVPSEAII
     M