ID   MPG1_HYPJE              Reviewed;         364 AA.
AC   O74624;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase;
GN   Name=mpg1;
OS   Hypocrea jecorina (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CATALYTIC ACTIVITY.
RC   STRAIN=ATCC 56765 / Rut C-30;
RX   PubMed=9644208; DOI=10.1007/s002940050358;
RA   Kruszewska J.S., Saloheimo M., Penttila M., Palamarczyk G.;
RT   "Isolation of a Trichoderma reesei cDNA encoding GTP: alpha-D-mannose-1-
RT   phosphate guanyltransferase involved in early steps of protein
RT   glycosylation.";
RL   Curr. Genet. 33:445-450(1998).
CC   -!- FUNCTION: Involved in cell wall synthesis where it is required for
CC       glycosylation. Involved in cell cycle progression through cell-size
CC       checkpoint (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC         Evidence={ECO:0000269|PubMed:9644208};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; U89991; AAC39498.1; -; mRNA.
DR   AlphaFoldDB; O74624; -.
DR   SMR; O74624; -.
DR   PRIDE; O74624; -.
DR   VEuPathDB; FungiDB:TrQ_006497; -.
DR   OMA; PFLTHQL; -.
DR   BRENDA; 2.7.7.13; 6451.
DR   UniPathway; UPA00126; UER00930.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cytoplasm; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..364
FT                   /note="Mannose-1-phosphate guanyltransferase"
FT                   /id="PRO_0000238493"
SQ   SEQUENCE   364 AA;  40285 MW;  66203BAF15284EBA CRC64;
     MKGLILVGGF GTRLRPLTLT LPKPLVEFCN KPMIVHQIEA LVAAGVTDIV LAVNYRPEIM
     EKFLAEYEEK YNINIEFSVE SEPLDTAGPL KLAERILGKD DSPFFVLNSD VICDYPFKEL
     LEFHKAHGDE GTIVVTKVEE PSKYGVVVHK PNHPSRIDRF VEKPVEFVGN RINAGMYIFN
     PSVLKRIELR PTSIEKETFP AMVADNQLHS FDLEGFWMDV GQPKDFLSGT CLYLSSLTKK
     GSKELTPPTE PYVHGGNVMI HPSAKIGKNC RIGPNVTIGP DVVVGDGVRL QRCVLLKGSK
     VKDHAWVKST IVGWNSTVGR WARLENVTVL GDDVTIGDEI YVNGGSVLPH KSIKANVDVP
     AIIM